Copper, Liver
Ordering Recommendation

May be useful when related serum or urine assessments are inconclusive. For the complete assessment of copper overload, Wilson Disease Screening Panel, Serum (0020598) is preferred.

Quantitative Inductively Coupled Plasma-Mass Spectrometry
Mon, Wed, Thu, Fri, Sat
2-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Liver tissue obtained with an 18 gauge needle. 
Specimen Preparation
Transport at least a 1 cm long specimen. Tissue can be fresh, paraffin-embedded, or dried. Also acceptable: Formalin-fixed. Specimens other than paraffin-embedded should be stored and transported in a metal-free container such as a royal blue (no additive). 
Storage/Transport Temperature
Unacceptable Conditions
Specimens less than 0.25 mg (dry weight). Paraffin blocks that have been processed with Hollandes or other copper-containing stain. 
Paraffin block, preserved (formalin), or dried: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely
Fresh tissue: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Indefinitely 
Reference Interval
15-55 µg/g of tissue.
Interpretive Data
Hepatic copper concentrations approach or exceed 250 µg/g in untreated Wilson disease. Elevated hepatic copper is also seen with chronic biliary obstruction and cholestatic conditions. Results inconsistent with other findings may reflect heterogeneity in hepatic copper distribution.

Statement B: Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
Component Test Code*Component Chart NameLOINC
0020695Tissue Weight29638-4
0020697Hepatic Copper Concentration by Weight56126-6
2004962EER Copper, Liver11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at
  • Copper Tissue
  • Cu
  • Hepatic Copper Concentration
  • Metals, Tissue
  • Quantitative Copper, Tissue