Copper, Serum or Plasma
0020096
Ordering Recommendation

Useful in the assessment of deficiency or overload. Copper, Serum Free (Direct) (0020596) may be a more specific indicator of copper overload. For the complete assessment of copper overload, Wilson Disease Screening Panel, Serum (0020598) is preferred.

Mnemonic
COPPER
Methodology
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). 
Collect
Royal Blue (No Additive), Royal Blue (K2 EDTA), or Royal Blue (Na2 EDTA). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL) 
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated or frozen. 
Unacceptable Conditions
Specimens collected in containers other than specified. Specimens transported in containers other than specified. 
Remarks
 
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely 
Reference Interval
Age
Male
Female
0-10 years75.0-153.0 µg/dL75.0-153.0 µg/dL
11 years-12 years64.0-132.0 µg/dL64.0-132.0 µg/dL
13 years-18 years57.0-129.0 µg/dL57.0-129.0 µg/dL
19 years and older70.0-140.0 µg/dL80.0-155.0 µg/dL

Interpretive Data
Elevated results may be due to skin or collection-related contamination, including the use of a noncertified metal-free collection/transport tube. If contamination concerns exist due to elevated levels of serum/plasma copper, confirmation with a second specimen collected in a certified metal-free tube is recommended.

Serum copper may be elevated with infection, inflammation, stress, and copper supplementation. In females, elevated copper may also be caused by oral contraceptives and pregnancy (concentrations may be elevated up to 3 times normal during the third trimester).

Serum copper may be reduced by use of corticosteroids and zinc and by malnutrition or malabsorption.

Statement B: Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Hotline History
View Hotline History
Components
Component Test Code*Component Chart NameLOINC
0020096Copper, Serum/Plasma5631-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please view this test within the Laboratory Test Directory found at www.aruplab.com
Aliases
  • Copper Plasma
  • Cu
  • Cu, Plasma
  • CUS
  • Kaiser Fleischer Ring
  • total blood copper level