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CSF Kappa Free Light Chains With Reflex to Oligoclonal Banding

CSF KFLC R

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Additional Technical Information

Ordering Recommendation

Used to assess for multiple sclerosis and other inflammatory central nervous system (CNS) diseases. This test is a quantitative alternative to the oligoclonal band assay.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

CSF AND serum separator tube or plain red

Specimen Preparation

Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transport two specimens. Transfer 1.5 mL CSF to an ARUP standard transport tube (Min: 0.7 mL) AND transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.6 mL).

Storage/Transport Temperature

Frozen

Unacceptable Conditions

Grossly bloody or hemolyzed specimens.

Remarks

Recommendation is for CSF and serum to be collected within 24 hours of each other. Specimens collected outside this timeframe will be accepted at ordering provider's discretion

Stability

Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 30 days

Methodology

Quantitative Immunoturbidimetry / Qualitative Isoelectric Focusing

Performed

Mon, Wed, Fri

Reported

1-5 days

Reference Interval

  Refer to report

Test Number
 Components
 Reference Interval
  Kappa Free Light Chains, CSF Less than 0.33 mg/L

Interpretive Data

  May be used in the assessment of multiple sclerosis or other inflammatory CNS diseases as a quantitative alternative to the oligoclonal band assay. This test screens for the presence of CSF kappa free light chains. Equivocal or positive results are reflexed to oligoclonal band testing.


Negative: Less than 0.33 mg/L
Equivocal: 0.33 mg/L-1.09 mg/L
Positive: Greater than 1.09 mg/L

Compliance Category

Laboratory Developed Test (LDT)

Note

  If Kappa Free Light Chains, CSF result is less than or equal to 0.33 m/L then Oligoclonal Bands in CSF and Serum (ARUP test code 0081135) will be added. Additional charges apply

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
07/20/2026
X
N/A

CPT Codes

83521; If reflexed, add 83916

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Components

Component Test Code* Component Chart Name LOINC
3021029 Kappa Free Light Chains, CSF 48774-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • cerebrospinal fluid
  • Kappa Free Light Chain, spinal fluid
  • Free Light Chain, cerebrospinal fluid
  • Free Light Chain, spinal fluid
  • Cerebrospinal fluid Free Light Chain
  • Spinal fluid Free Light Chain
  • Multiple Sclerosis
  • MS
  • Oligoclonal Banding
CSF Kappa Free Light Chains With Reflex to Oligoclonal Banding