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CYP2C19
Ordering Recommendation
Assesses genetic risk of abnormal drug metabolism for CYP2C19 substrates. May aid in drug selection and dose planning for drugs metabolized by CYP2C19.
New York DOH Approval Status
Specimen Required
Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B).
Transport 3 mL whole blood. (Min: 1 mL)
Preferred transport temp: Refrigerated.
Plasma or serum. Specimens collected in sodium heparin or lithium heparin. Frozen specimens in glass collection tubes.
Counseling and informed consent are recommended for genetic testing. Consent forms are linked above.
New York Clients: Informed consent is required with submission.
Room temperature: 3 days; Refrigerated: 1 week; Frozen: 1 month
Methodology
Polymerase Chain Reaction (PCR) / Fluorescence Monitoring
Performed
Varies
Reported
5-10 days
Reference Interval
Refer to report
Interpretive Data
Refer to report
Laboratory Developed Test (LDT)
Note
Hotline History
CPT Codes
81225
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2008936 | CYP2C19 Phenotype | 79714-2 |
| 3001509 | 2C19GENO Specimen | 31208-2 |
| 3001510 | CYP2C19 Genotype | 57132-3 |
| 3001511 | 2C19GENO Interpretation | 50398-7 |
| 3016869 | EER CYP2C19 | 11526-1 |
Aliases
- 2C19
- amitriptyline
- antidepressants
- clomipramine
- clopidogrel
- CYP2C19
- Cytochrome P450 2C19 Genotype
- dexlansoprazole
- doxepine
- escitalopram
- imipramine
- lansoprazole
- omeprazole
- pantoprazole
- Plavix
- PPIs
- protein pump inhibitors
- rabeprazole
- sertraline
- SSRI
- TCA
- trimipramine
- voriconazole
