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MYCN (N-MYC) Gene Amplification by FISH
3001307
Ordering Recommendation

Prognostic determination in individuals with neuroblastoma or medulloblastoma.

Mnemonic
NMYC_FISH
Methodology
Fluorescence in situ Hybridization
Performed
Monday-Friday
Reported
3-7 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Tumor tissue. 
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin-embed tissue. Protect paraffin block from excessive heat. Transport block or 5 unstained (4 micron thick sections) positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787 (kit recommended but not necessary). (Min 2 slides) 
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months. 
Unacceptable Conditions
Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens. 
Remarks
Include surgical pathology report. 
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable 
Reference Interval
Interpretive Data
Refer to report.

Compliance Statement A: For laboratory developed tests using a manufacturer labeled ASR as the reagent providing the specificity of the assay. Analyte Specific Reagent. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, the FDA has determined that such clearance or approval is not necessary.

Note
Hotline History
View Hotline History
Components
Component Test Code*Component Chart NameLOINC
3000647MYCN FISH Reference Number
3000648MYCN FISH Source
3000649MYCN/CEP2 FISH Ratio
3000650Average MYCN Signal Number per Cell
3000651Average CEP2 Signal Number per Cell
3000652MYCN FISH Result
3000702Total Cell Count
3000703Scoring Method
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 2p24
  • MYCN IHC
  • MycN immunostaining