Comprehensive Systemic Sclerosis Panel
Ordering Recommendation

Comprehensive evaluation of systemic scleroderma/sclerosis (SSc). Indicated when suspicion for SSc is high and patient presents with features of overlap syndrome. For patients with distinct features of SSc, order Criteria Systemic Sclerosis Panel (3000479).

Qualitative Immunoblot/Semi-Quantitative Indirect Fluorescent Antibody/Semi-Quantitative Multiplex Bead Assay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
1-8 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum Separator Tube (SST). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1.5 mL) 
Storage/Transport Temperature
Refrigerated. Also acceptable: Room temperature or frozen. 
Unacceptable Conditions
Hemolyzed, hyperlipemic, icteric, heat-treated or contaminated specimens 
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year 
Reference Interval
Test Number
Reference Interval
0050599Scleroderma (Scl-70) (ENA) Antibody, IgG
29 AU/mL or lessNegative
30-40 AU/mLEquivocal
41 AU/mL or greaterPositive

0050470Smith/RNP (ENA) Antibody, IgG
29 AU/mL or lessNegative
30-40 AU/mLEquivocal
41 AU/mL or greaterPositive

3000082Antinuclear Antibody (ANA) with HEp-2 Substrate, IgG by IFALess than 1:80
2012173Fibrillarin (U3 RNP) Antibody, IgGNegative
2003040PM/Scl-100 Antibody, IgG by ImmunoblotNegative
2001601RNA Polymerase III Antibody, IgG
19 Units or lessNegative
20-39 UnitsWeak Positive
40-80 UnitsModerate Positive
81 Units or greaterStrong Positive

Interpretive Data
Refer to report.

Panel includes: Antinuclear Antibody (ANA) with HEp-2 Substrate, IgG by IFA, Scleroderma (Scl-70) (ENA) Antibody, IgG, RNA Polymerase III Antibody, IgG, Smith/RNP (ENA) Antibody, IgG, Fibrillarin (U3 RNP) Antibody, IgG, PM/Scl-100 Antibody, IgG by Immunoblot.
Hotline History
View Hotline History
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0050470Smith/RNP (ENA) Ab, IgG33983-8
0050599Scleroderma (Scl-70) (ENA) Antibody, IgG47322-3
2001602RNA Polymerase III Antibody, IgG79182-2
2003041PM/Scl 100 Antibody, IgG81732-0
2012174Fibrillarin (U3 RNP) Ab, IgG49963-2
3000090Antinuclear Antibody (ANA), HEp-2, IgG21424-7
3000096ANA Interpretive Comment49311-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.