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Thiopurine Metabolites by LC-MS/MS
2014484
Ordering Recommendation

Phenotype test used to optimize therapy for patients who are taking thiopurine drugs. Thiopurine metabolite concentrations are identified to assess therapeutic and toxic concentrations. If thiopurine therapy has not been initiated, order Thiopurine Methyltransferase, RBC (0092066).

Mnemonic
THIOPMETAB
Methodology
Quantitative Liquid Chromatography/Tandem Mass Spectrometry
Performed
Varies
Reported
3-7 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
Trough collection (within 1 hour prior to the next dose). 
Collect
Lavender (EDTA) or Pink (K2EDTA). 
Specimen Preparation
Transport 5 mL whole blood. (Min: 2.5 mL) 
Storage/Transport Temperature
Refrigerated. Send Sunday - Wednesday only. 
Unacceptable Conditions
Hemolyzed specimens. 
Remarks
 
Stability
Ambient: 24 hours; Refrigerated: 5 days; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data


Note
Hotline History
View Hotline History
Components
Component Test Code*Component Chart NameLOINC
20144856-Thioguanine32660-3
20144866-Methylmercaptopurine32654-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 6 Methyl Mercaptopurine
  • 6-MMP
  • 6-MP
  • 6-TG
  • AZA
  • Imuran Metabolite
  • TPMT

Performed at Quest Diagnostics San Juan Capistrano Inc.