IDH1/IDH2 mutational status is a prognostic marker in individuals with low- and high-grade gliomas. Aid in distinguishing a primary from a secondary glioblastoma.
N/A
- Patient Preparation
- Collect
- Collect: Tumor tissue.
- Specimen Preparation
- Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block or 4 unstained 5-micron slides. (Min: 3 slides) Transport block and/or slide(s) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™or contact ARUP Client Services at (800) 522-2787.
- Storage/Transport Temperature
- Room temperature. Also acceptable: Refrigerated. Ship in cooled containers during summer months.
- Unacceptable Conditions
- No tumor in tissue. Specimens fixed/processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). Decalcified specimens.
- Remarks
- For FFPE specimens include surgical pathology report. Tissue block will be returned after testing.
- Stability
- Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2002148 | Block ID | 57723-9 |
2006445 | IDH1 and IDH2 Mutation Results | 35474-6 |
2014216 | IDH1-2 FFPE Source |
- IDH1
- IDH1 SNP
- IDH2
- Isocitrate dehydrogenase (IDH) 1 and 2
- Isocitrate Dehydrogenase 1
- Isocitrate Dehydrogenase 2
- NADP+