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Prostate-Specific Kallikrein, 4Kscore
2014059
Ordering Recommendation

Test intended for patients age 40-80. Stratifies risk of aggressive prostate cancer in patients with elevated PSA where biopsy is being considered. Test should not be ordered if (1) prostate cancer was previously diagnosed; (2) digital rectal exam was performed within the last 4 days; (3) any procedure or therapy was used to treat symptomatic benign prostatic hyperplasia (BPH) within the past 6 months; (4) any invasive, urologic procedure that may be associated with a secondary PSA evaluation was done within the past 6 months; (5) 5-alpha reductase inhibitor (5-ARI) therapy, such as Avodart (dutasteride) or Proscar (finasteride), was administered within the past 6 months.

Mnemonic
4KSCORE
Methodology
Electrochemiluminescent Immunoassay
Performed
Varies
Reported
3-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum Separator Tube (SST). 
Specimen Preparation
Transfer 4 mL serum to an ARUP Standard Transport Tube. (Min: 3 mL) 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
 
Remarks
Test must be discussed with patient prior to ordering. Patient history, biopsy history and digital rectal exam (DRE) results are required for testing. 
Stability
Ambient: Unacceptable; Refrigerated: 72 hours; Frozen: 1 month 
Reference Interval
By report
Interpretive Data


Note
4 Kallikrein Biomarkers: Total PSA, Free PSA, percent free PSA, Intact PSA and hK2. Test should not be ordered if Digital Rectal Exam (DRE) has been performed within the last 4 days or if biopsy history is positive.
Hotline History
View Hotline History
CPT Code(s)
81539
Components
Component Test Code*Component Chart NameLOINC
20140604K - Biopsy History
20140614K - Digital Rectal Exam (DRE)
20140634K - Score
20140644K - Negative Predictive Value (NPV)
20143094K - PSA, Total
20143104K - PSA, Free
20143114K - PSA, Percent Free
30005864K - Order Discussed with Patient
30005874K - Patient History
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 4K Prostate Screen; Prostate test
  • Kallikrein score

Performed at BioReference Laboratories