Prostate-Specific Kallikrein, 4Kscore
2014059
Ordering Recommendation
Test intended for patients age 40-80. Stratifies risk of aggressive prostate cancer in patients with elevated PSA where biopsy is being considered. Test should not be ordered if (1) prostate cancer was previously diagnosed; (2) digital rectal exam was performed within the last 4 days; (3) any procedure or therapy was used to treat symptomatic benign prostatic hyperplasia (BPH) within the past 6 months; (4) any invasive, urologic procedure that may be associated with a secondary PSA evaluation was done within the past 6 months; (5) 5-alpha reductase inhibitor (5-ARI) therapy, such as Avodart (dutasteride) or Proscar (finasteride), was administered within the past 6 months.
Mnemonic
4KSCORE
Methodology
Electrochemiluminescent Immunoassay
Performed
Varies
Reported
3-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
- Patient Preparation
- Collect
- Serum Separator Tube (SST).
- Specimen Preparation
- Transfer 4 mL serum to an ARUP Standard Transport Tube. (Min: 3 mL)
- Storage/Transport Temperature
- Frozen.
- Unacceptable Conditions
- Remarks
- Stability
- Ambient: Unacceptable; Refrigerated: 72 hours; Frozen: 1 month
Reference Interval
By report
Interpretive Data
Note
4 Kallikrein Biomarkers: Total PSA, Free PSA, percent free PSA, Intact PSA and hK2. Test should not be ordered if Digital Rectal Exam (DRE) has been performed within the last 4 days or if biopsy history is positive.
CPT Code(s)
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2014060 | 4K - Biopsy History | |
| 2014061 | 4K - Digital Rectal Exam (DRE) | |
| 2014063 | 4K - Score | |
| 2014064 | 4K - Negative Predictive Value (NPV) | |
| 2014309 | 4K - PSA, Total | |
| 2014310 | 4K - PSA, Free | |
| 2014311 | 4K - PSA, Percent Free |
Aliases
- 4K Prostate Screen; Prostate test
- Kallikrein score
Performed at BioReference Laboratories