Prostate-Specific Kallikrein, 4Kscore
Ordering Recommendation

Test intended for patients age 40-80. Stratifies risk of aggressive prostate cancer in patients with elevated PSA where biopsy is being considered. Test should not be ordered if (1) prostate cancer was previously diagnosed; (2) digital rectal exam was performed within the last 4 days; (3) any procedure or therapy was used to treat symptomatic benign prostatic hyperplasia (BPH) within the past 6 months; (4) any invasive, urologic procedure that may be associated with a secondary PSA evaluation was done within the past 6 months; (5) 5-alpha reductase inhibitor (5-ARI) therapy, such as Avodart (dutasteride) or Proscar (finasteride), was administered within the past 6 months.

Electrochemiluminescent Immunoassay
3-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum Separator Tube (SST). 
Specimen Preparation
Transfer 4 mL serum to an ARUP Standard Transport Tube. (Min: 3 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Test must be discussed with patient prior to ordering. Patient history, biopsy history and digital rectal exam (DRE) results are required for testing. 
Ambient: Unacceptable; Refrigerated: 72 hours; Frozen: 1 month 
Reference Interval
By report
Interpretive Data

4 Kallikrein Biomarkers: Total PSA, Free PSA, percent free PSA, Intact PSA and hK2. Test should not be ordered if Digital Rectal Exam (DRE) has been performed within the last 4 days or if biopsy history is positive.
Hotline History
View Hotline History
Component Test Code*Component Chart NameLOINC
20140604K - Biopsy History
20140614K - Digital Rectal Exam (DRE)
20140634K - Score
20140644K - Negative Predictive Value (NPV)
20143094K - PSA, Total
20143104K - PSA, Free
20143114K - PSA, Percent Free
30005864K - Order Discussed with Patient
30005874K - Patient History
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • 4K Prostate Screen; Prostate test
  • Kallikrein score

Performed at BioReference Laboratories