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Paraneoplastic Reflexive Panel
2013955
Ordering Recommendation

Aid in the diagnosis of paraneoplastic neurological syndromes associated with ANNA-1 (Hu), ANNA-2 (Ri), PCCA-1 (Yo), amphiphysin, and CV2.1 antibodies.

Mnemonic
PNS PAN
Methodology
Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot
Performed
Wed
Reported
1-9 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum Separator Tube (SST) 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 3 mL serum aliquot to an ARUP Standard Transport Tube. (Min: 1.0 mL) 
Storage/Transport Temperature
Refrigerated 
Unacceptable Conditions
Contaminated, heat-inactivated, hemolyzed, or lipemic specimens 
Remarks
 
Stability
After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 1 year 
Reference Interval
Test Number
Components
Reference Interval
2013956CV2.1 Screen by IFA with Reflex to TiterLess than 1:10
2007961Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot
Test Number
Components
Reference Interval
Purkinje Cell/Neuronal Nuclear IgG ScrnNone Detected
Neuronal Nuclear Antibody (ANNA) IFA Titer, IgGLess than 1:10
Purkinje Cell Antibody, TiterLess than 1:10
2007963Neuronal Nuclear Antibodies (Hu, Ri, Yo) IgG by ImmunoblotRefer to report

2008893Amphiphysin Antibody, IgGNegative

Interpretive Data
Refer to report

Compliance Statement D: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, and Yo) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, and Yo) IgG by Immunoblot will be added. Additional charges apply. If CV2.1 Antibody IgG Screen by IFA is positive, then CV2.1 Antibody IgG Titer by IFA will be added. Additional charges apply.
CPT Code(s)
86255 x2; 83516; if reflexed add 86256 and/or 83516; if reflexed add 86256
Components
Component Test Code*Component Chart NameLOINC
0051709Neuronal Antibody (Amphiphysin)57749-4
2007962Purkinje Cell/Neuronal Nuclear IgG Scrn61177-2
2013959CV2.1 Antibody IgG Screen by IFA
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases