Comprehensive panel for the evaluation of paraneoplastic and neuromuscular junction disorders, and/or encephalitis, in the presence or absence of malignancy.
- Patient Preparation
- Serum Separator Tube (SST)
- Specimen Preparation
- Separate from cells ASAP or within 2 hours of collection. Transfer three 3 mL serum aliquots to ARUP Standard Transport Tubes. (Min: 1.50 mL/aliquot)
- Storage/Transport Temperature
- Unacceptable Conditions
- Amniotic fluid, ocular fluid, peritoneal fluid, synovial fluid, CSF, or plasma. Contaminated, hemolyzed, icteric, or lipemic specimens.
- After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 1 month (avoid repeated freeze/thaw cycles)
|Test Number||Components||Reference Interval|
|0050746||Striated Muscle Antibodies, IgG with Reflex to Titer||Less than 1:40|
|2004221||N-methyl-D-Aspartate Receptor Antibody, IgG, Serum with Reflex to Titer||< 1:10|
|2001771||Glutamic Acid Decarboxylase Antibody||0.0-5.0 IU/mL|
|2013956||CV2.1 Screen by IFA with Reflex to Titer||Less than 1:10|
|0092628||Voltage-Gated Calcium Channel (VGCC) Antibody||Effective November 14, 2011|
|2005636||Titin Antibody||Effective January 17, 2012|
|2004890||Voltage-Gated Potassium Channel (VGKC) Antibody|
|2003036||Aquaporin-4 Receptor Antibody||Effective October 3, 2016|
|0080009||Acetylcholine Receptor Binding Antibody||Negative: 0.0-0.4 nmol/L|
Positive: 0.5 nmol/L or greater
|2007961||Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot|
|2008893||Amphiphysin Antibody, IgG||Negative|
If N-methyl-D-Aspartate Receptor Antibody is positive, then titer will be added. Additional charges apply.
If CV2.1 Antibody IgG Screen by IFA is positive, then a titer will be added. Additional charges apply.
If Aquaporin-4 Receptor Antibody IgG by ELISA is positive, then Aquaporin-4 Receptor Antibody, IgG by IFA will be added. If positive, then a titer will be added. Additional charges apply.
If Voltage-Gated Calcium Channel (VGCC) Antibody is Indeterminate or Positive, then Leucine-Rich, Glioma-Inactivated Protein 1 Antibody IgG and Contactin-Associated Protein-2 Antibody IgG will be added. If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
If Acetylcholine Receptor Binding Antibody result is greater than 0.4 nmol/L then Acetylcholine Receptor Modulating Antibody will be added. Additional charges apply.
Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, and Yo) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, and Yo) IgG by Immunoblot will be added. Additional charges apply.
|Component Test Code*||Component Chart Name||LOINC|
|0050747||Striated Muscle Antibodies, IgG Screen||49692-7|
|0051709||Neuronal Antibody (Amphiphysin)||57749-4|
|0080009||Acetylcholine Binding Antibody||11034-6|
|0092629||Voltage-Gated Calcium Channel (VGCC) Ab||33980-4|
|2001772||Glutamic Acid Decarboxylase Antibody||56540-8|
|2003121||Aquaporin-4 Receptor Antibody||61430-5|
|2004222||N-methyl-D-Aspartate Receptor Ab, Serum||80221-5|
|2004890||Voltage-Gated Potassium Channel (VGKC)Ab||41871-5|
|2007962||Purkinje Cell/Neuronal Nuclear IgG Scrn||61177-2|
|2013959||CV2.1 Antibody IgG Screen by IFA|