Determine BRAF V600E mutation status in patients with solid tumors to select candidates for targeted therapy with kinase inhibitors (BRAF and/or MEK). Monitor response to therapy and disease progression in patients carrying BRAF V600E mutation.
- Patient Preparation
- Collect
- Whole blood in two 10mL Cell-Free DNA (cfDNA) BCT Tubes. Specimens must be collected using the Kit, Cell-Free DNA Blood Collection Tube (ARUP Supply #52358) available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787.
- Specimen Preparation
- Transport 20 mL whole blood in cfDNA BCT Tubes. (Min: 16 mL)
- Storage/Transport Temperature
- Refrigerated.
- Unacceptable Conditions
- FFPE tissue. Whole blood collected in non-cfDNA BCT tubes.
- Remarks
- Stability
- Ambient: 5 days; Refrigerated: 5 days; Frozen: Unacceptable
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2013922 | BRAF V600E cfDNA Result | 58415-1 |
2013924 | BRAF V600E cfDNA Mutant Allele Frequency | |
2013925 | BRAF V600E cfDNA Mutant copies/mL |