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Epi proColon
2013906
Ordering Recommendation

The Epi proColon test is indicated to screen adults of either sex, 50 years or older, defined as average risk for CRC, who have been offered and have a history of not completing CRC screening. Tests that are available and recommended in the USPSTF 2008 CRC screening guidelines should be offered and declined prior to offering the Epi proColon test. Patients with a positive Epi proColon test result should be referred for diagnostic colonoscopy. The Epi proColon test results should be used in combination with physician's assessment and individual risk factors in guiding patient management.

Mnemonic
EPIPRO
Methodology
Polymerase Chain Reaction
Performed
Sun, Wed
Reported
7-10 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lavender (K2EDTA). Collect a minimum of 10 mL whole blood. Blood collection tubes should be allowed to complete the evacuated fill. 
Specimen Preparation
Plasma preparation should be performed ASAP or within 4 hours of collection. Centrifuge for 12 min at 1350 ± 150 rcf. Transfer the plasma to a 15 mL conical tube and centrifuge for an additional 12 minutes at 1350 ± 150 rcf. Ensure a minimum of 3.5 mL of plasma is obtained following centrifugation. Transfer entire plasma aliquot to a cryovial tube or any freezable specimen transport tube. (Min: 3.5 mL) 
Storage/Transport Temperature
Frozen. Also acceptable: Refrigerated. 
Unacceptable Conditions
Serum, stool, or whole blood. Hemolyzed specimens. 
Remarks
 
Stability
Ambient: Unacceptable; Refrigerated: 72 hours; Frozen: 2 weeks 
Reference Interval
Interpretive Data
Refer to report.

Note
This test is not intended to replace a colonoscopy. NOT recommended for pregnant women because of a potential for false-positive results in these individuals.

Accurate test performance requires following the specimen preparation instructions. Minimum volume of 3.5 mL is required for testing without repeats. If a repeat is necessary, an additional specimen will be requested.
Components
Component Test Code*Component Chart NameLOINC
2013907Epi proColon Result65810-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ColoVantage
  • mS9
  • Septin 9
  • Septin 9 methylation