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Candida FKS Drug Resistance by Sequencing
2013901
Ordering Recommendation

Detect known echinocandin resistance mutations in C. albicans, C. glabrata, C. krusei, C. parapsilosis, and C. tropicalis.

Mnemonic
FKS SEQ
Methodology
Polymerase Chain Reaction/Sequencing
Performed
Sun, Mon, Wed
Reported
3-5 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Body fluid, tissue, or pure isolate of Candida species on solid media. 
Specimen Preparation
Body Fluid: Transfer 1 mL body fluid to a sterile container. (Min: 0.5 mL)
Tissue: Transfer to a sterile container and freeze immediately.
Isolate: Transport sealed container with pure isolate on solid media. Place each specimen in an individually sealed bag. 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Plasma, serum, or whole blood. Mixed cultures or isolates other than suspected Candida species. Isolates with no visible colonies. 
Remarks
Specimen source and organism identification required. 
Stability
Body Fluid: Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 weeks
Tissue: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 2 weeks
Isolate: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: Unacceptable 
Reference Interval
Interpretive Data
This assay detects known resistance mutations in C. albicans, C. glabrata, C. krusei, C. parapsilosis, and C. tropicalis by sequencing. The FKS1 and FKS2 genes are sequenced. Mutations associated with resistance to Echinocandins are reported. Mutations in sub-populations below 20 percent of total may not be detected.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
This test may be unsuccessful if the specimen or isolate does not contain C. albicans, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis, or if multiple Candida species are present.
Components
Component Test Code*Component Chart NameLOINC
2013785Candida Species Source31208-2
2013902FKS Drug Resistance by Sequencing
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases