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Hereditary Gastrointestinal Cancer Panel, Sequencing and Deletion/Duplication
2013449
Ordering Recommendation

Confirm a diagnosis of hereditary gastrointestinal (GI) cancer in individuals with a personal or family history of GI cancer and/or polyposis.

Mnemonic
GICAN PAN
Methodology
Massively Parallel Sequencing/Exonic Oligonucleotide-based CGH Microarray/Sequencing/Multiplex Ligation-dependent Probe Amplification
Performed
Varies
Reported
3-6 weeks
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA) or Yellow (ACD Solution A or B). 
Specimen Preparation
Transport 3 mL whole blood. (Min: 1 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
 
Remarks
 
Stability
Ambient: 72 hours; Refrigerated: 1 week; Frozen: Unacceptable 
Reference Interval
By report
Interpretive Data
Refer to report.

Compliance Statement C: For human genetic inheritable conditions and mutations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Counseling and informed consent are recommended for genetic testing. Consent forms are available online.

Note
Genes Tested: APC, AXIN2**, BMPR1A, CDH1, CHEK2*, EPCAM****, MLH1, MSH2, MSH3**, MSH6, MUTYH, NTHL1, PMS2, POLD1, POLE, PTEN, SDHB, SDHC*, SDHD*, SMAD4, STK11, TP53
 
* One or more exons are not covered by sequencing for the indicated gene; see Additional Technical Information.
** Deletion/duplication detection is not available for this gene.
**** Deletion/duplication only; sequencing is not available for this gene.
Hotline History
View Hotline History
Components
Component Test Code*Component Chart NameLOINC
2010199Gastrointestinal Cancer Panel - Spcmn31208-2
2013450Gastrointestinal Cancer Panel - Interp41103-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Cowden syndrome
  • Familial Adenomatous Polyposis (FAP)
  • Hereditary Diffuse Gastric Cancer (HDGC)
  • Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
  • Hereditary Paraganglioma Pheochromocytoma syndrome
  • Juvenile polyposis
  • Juvenile Polyposis syndrome (JPS)
  • Li-Fraumeni syndrome (LFS)
  • Lynch
  • Lynch syndrome
  • MUTYH-associated polyposis (MAP)
  • Peutz Jegher syndrome (PJS)