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Systemic Sclerosis Comprehensive Panel
2013325
Ordering Recommendation

Comprehensive evaluation of systemic scleroderma/sclerosis (SSc). Indicated when suspicion for SSc is high and patient presents with features of overlap syndrome.

Mnemonic
SCL COMP
Methodology
Qualitative Immunoblot/Semi-Quantitative Indirect Fluorescent Antibody/Semi-Quantitative Multiplex Bead Assay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Thu
Reported
1-8 days
N/A
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
N/A 
Collect
Serum Separator Tube (SST) 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1.5 mL) 
Storage/Transport Temperature
Refrigerated. Also acceptable: Room temperature or frozen. 
Unacceptable Conditions
Hemolyzed, hyperlipemic, icteric, heat-treated or contaminated specimens 
Remarks
N/A 
Stability
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year 
Reference Interval
Test Number
Components
Reference Interval
0050599Scleroderma (Scl-70) (ENA) Antibody, IgG29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive
0050470RNP (U1) (Ribonucleic Protein) (ENA) Antibody, IgG
29 AU/mL or lessNegative
30-40 AU/mLEquivocal
41 AU/mL or greaterPositive

0050639Nuclear Antibody (ANA) by IFA, IgGLess than 1:40
2012173Fibrillarin (U3 RNP) Antibody, IgGNegative
2003040PM/Scl-100 Antibody, IgG by ImmunoblotNegative
2001601RNA Polymerase III Antibody, IgG19 Units or less: Negative
20-39 Units: Weak Positive
40-80 Units: Moderate Positive
81 Units or greater: Strong Positive

Interpretive Data
Refer to report

Note
Panel includes: Anti-Nuclear Ab (ANA) Titer, Anti-Nuclear Ab (ANA) Pattern, Anti-Scl-70, Anti-RNA Polymerase III Ab, Anti-U1 RNP Ab, Anti-Fibrillarin (U3 RNP), Anti-PM/Scl-100 Ab
CPT Code(s)
Components
Component Test Code*Component Chart NameLOINC
0050470Ribonucleic Protein (U1) (ENA) Ab, IgG33983-8
0050599Scleroderma (Scl-70) (ENA) Antibody, IgG47322-3
0050639Anti-Nuclear Antibody (ANA), IgG by IFA56634-9
2001602RNA Polymerase III Antibody, IgG79182-2
2003041PM/Scl 100 Antibody, IgG81732-0
2012174Fibrillarin (U3 RNP) Ab, IgG49963-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases