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Lysosomal Acid Lipase Activity, Dried Blood Spot
2012266
Ordering Recommendation
Mnemonic
LAL DBS
Methodology
Quantitative Fluorometry
Performed
Varies
Reported
3-10 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Dried Blood Spot (DBS): Whatman 903 Protein Saver Card (filter paper).
Whole blood: Yellow (ACD Solution A). Also Acceptable: Lavender (K2EDTA), Lavender (K3EDTA) or Green (Sodium heparin). 
Specimen Preparation
DBS: Whole blood collected on filter paper by direct puncture and dried.
Whole blood collected by venipuncture in Yellow (ACD Solution A) or Lavender (K2EDTA), Lavender (K3EDTA) or Green (Sodium heparin) and then spotted on filter paper and dried.
Allow blood to completely air dry before transporting for a minimum of 4 hours to overnight. Two circles of whole blood. (Min: 1 circle)
Whole Blood: Transport 1 mL whole blood. (Min: 0.5 mL) 
Storage/Transport Temperature
DBS: Room temperature. Also acceptable: Refrigerated.
Whole Blood: Refrigerated. Also acceptable: Room temperature. 
Unacceptable Conditions
DBS: Samples transported before blood is dried. Blood not soaked through to the back of the filter paper card. Heavily saturated, clotted, or double-spotted samples. Samples with evidence of milking or squeezing the puncture site or of contamination by alcohol or other liquids. 
Remarks
Additional information is required: Clinical Indication for testing. 
Stability
DBS: Ambient : 1 week; Refrigerated: 1 week; Frozen: 1 month
Whole Blood: Ambient : 3 days; Refrigerated: 3days; Frozen: Unacceptable 
Reference Interval
0.50 - 2.30 nmol hydrolyzed/hr/DBS punch
Interpretive Data
Refer to report.
Lysosomal acid lipase activity is reported in nanomoles hydrolyzed per hr per DBS punch.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Components
Component Test Code*Component Chart NameLOINC
2012267Lysosomal Acid Lipase, DBS Interp48767-8
2012268Lysosomal Acid Lipase, Dried Blood Spot73958-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CESD
  • Cholesterol Ester Storage Disease
  • LAL deficiency
  • LIPA deficiency
  • Lysosomal acid lipase deficiency
  • Wolman Disease