Detects important genomic abnormalities in acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), and MDS/MPN neoplasms that may have diagnostic, prognostic, and/or therapeutic significance:
• Loss/gain of DNA
• Loss of heterozygosity (LOH)
• Single gene mutations (substitutions and small insertions and deletions)
- Patient Preparation
- Collect
- Lavender (EDTA) OR bone marrow (EDTA).
- Specimen Preparation
- Do not freeze. Transport 5 mL whole blood. (Min: 1 mL) OR Transport 3 mL bone marrow. (Min: 1 mL)
- Storage/Transport Temperature
- Refrigerated.
- Unacceptable Conditions
- Serum, plasma or tissue. Specimens collected in anticoagulants other than EDTA. Clotted or grossly hemolyzed specimens.
- Remarks
- Stability
- Ambient: 24 hours; Refrigerated: 5 days; Frozen: Unacceptable
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2006326 | Cytogenomic Microarray SNP - Oncology | |
2011118 | Myeloid Malignancy Proposed Diagnosis | |
2011119 | Myeloid Malignancies Panel Specimen | 31208-2 |
2011120 | Myeloid Malignancies Panel Interp | 35474-6 |
2012183 | Myeloid Panel Summary |
- Acute myeloid leukemia, AML
- Aplastic Anemia
- ASXL1, ASXL2, BCOR, BCORL1, BRAF, BRINP3/FAM5C, CALR, CBL, CEBPA, CSF3R, DNMT1, DNMT3A
- Atypical chronic myelogenous leukemia
- Chronic eosinophilic leukemia not otherwise specified
- Chronic myelogenous leukemia, BCR-ABL1 positive
- Chronic myelomonocytic leukemia, CMML
- Chronic neutrophilic leukemia
- EED, ELANE, ETNK1, ETV6, EZH2, FLT3, GATA1, GATA2, HNRNPK, IDH1, IDH2, JAK2, JAK3, KDM6A, KIT
- Genomic microarray
- Juvenile myelomonocytic leukemia, JMML
- KMT2A/MLL, KRAS, LUC7L2, MAP2K1, MPL, NOTCH1, NPM1, NRAS, NSD1, PHF6, PRPF40B, PRPF8, PTPN11
- Mastocytosis
- Myelodysplastic syndrome with isolated del(5q)
- Myelodysplastic syndromes
- Myelodysplastic/Myeloproliferative neoplasm
- Myeloproliferative neoplasm
- Myeloproliferative neoplasm, essential thrombocythemia
- Myeloproliferative neoplasm, polycythemia vera
- Myeloproliferative neoplasm, primary myelofibrosis
- Oligo-SNP array
- RAD21, RUNX1, SETBP1, SF1, SF3A1, SP3B1, SMC1A, SMC3, SRSF2, STAG2, SUZ12
- Refractory anemia with excess blasts, RAEB
- Refractory anemia with ring sideroblasts associated with marked thrombocytosis, RARS-T
- Refractory anemia with ring sideroblasts, RARS
- Refractory cytopenia with multilineage dysplasia, RCMD
- Refractory cytopenia with unilineage dysplasia, RCUD
- TET2, TP53, U2AF1, U2AF2,WT1, ZRSR2