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Systemic Sclerosis Panel
2012057
Ordering Recommendation

Indicated for patients with distinct features of systemic scleroderma (SSc). For a more comprehensive panel that includes U3 RNP (fibrillarin), PM/Scl-100, and U1RNP, refer to Systemic Sclerosis Comprehensive Panel (2013325).

Mnemonic
SSC PAN
Methodology
Semi-Quantitative Indirect Fluorescent Antibody/Semi-Quantitative Multiplex Bead Assay/ Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun, Tue, Thu
Reported
1-3 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum Separator Tube (SST). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 0.25 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Contaminated, hemolyzed, or severely lipemic specimens. 
Remarks
 
Stability
Ambient 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles) 
Reference Interval
Test Number
Components
Reference Interval
0050639Nuclear Antibody (ANA) by IFA, IgGEffective November 13, 2017
Less than 1:80
0050599Scleroderma (Scl-70) (ENA) Antibody, IgG
29 AU/mL or lessNegative
30-40 AU/mLEquivocal
41 AU/mL or greaterPositive

2001601RNA Polymerase III Antibody, IgG
19 Units or lessNegative
20-39 UnitsWeak Positive
40-80 UnitsModerate Positive
81 Units or greaterStrong Positive


Interpretive Data
Refer to report.

Note
CPT Code(s)
Components
Component Test Code*Component Chart NameLOINC
0050599Scleroderma (Scl-70) (ENA) Antibody, IgG47322-3
0050639Anti-Nuclear Antibody (ANA), IgG by IFA56634-9
2001602RNA Polymerase III Antibody, IgG79182-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ANA
  • Antinuclear Antibodies
  • Antinuclear Antibody
  • FANA
  • Fluorescent Antinuclear Antibodies