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Lysozyme, Serum
2012039
Ordering Recommendation

Aids in diagnosis of acute myelocytic leukemia or other leukemias, sarcoidosis, and infections such as tuberculosis.

Mnemonic
LYSO SER
Methodology
Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun, Tue, Thu
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube (SST). 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Hemolyzed, lipemic, icteric, or contaminated specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 8 hours; Refrigerated: 1 week; Frozen: 3 months. 
Reference Interval
0.00-2.75 µg/mL
Interpretive Data


Note
Serum lysozyme levels may be elevated in acute myelomonocytic leukemia (FAB-M4), chronic myelomonocytic leukemia (CMML), and chronic myelocytic leukemia (CML). Increased serum lysozyme activity is present in tuberculosis, sarcoidosis, megaloblastic anemias, acute bacterial infections, ulcerative colitis, regional enteritis, and Crohn disease. Elevated serum lysozyme occurs during severe renal insufficiency, renal transplant rejection, urinary tract infections, pyelonephritis, glomerulonephritis, and nephrosis.
CPT Code(s)
85549
Components
Component Test Code*Component Chart NameLOINC
2012040Lysozyme, Serum2589-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Muramidase serum
  • Serum lysozyme