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Fentanyl and Metabolite, Serum or Plasma, Quantitative
2011776
Ordering Recommendation

Monitor patient adherence.

Mnemonic
CDCO FNSP
Methodology
Quantitative Liquid Chromatography/Tandem Mass Spectrometry
Performed
Tue, Thu, Sat
Reported
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Plain Red, Lavender (K2EDTA), Lavender (K3EDTA), Green (Sodium Heparin), Gray (Potassium Oxalate/Sodium Fluoride), or Pink (K2EDTA). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 4 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 2 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Whole blood. Serum separator tubes, Light Blue (Sodium Citrate), or Plasma separator tubes. Specimens exposed to repeated freeze/thaw cycles. 
Remarks
Please indicate in the supplied fields:
1.  Dose - List drug amount and include the units of measure
2.  Route - List the route of administration (IV, oral, etc.)
3.  Dose Frequency - Indicate how often the dose is administered (per day, per week, as needed, etc.)
4.  Type of Draw - Indicate the type of blood draw (Peak, Trough, Random, etc.) 
Stability
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years 
Reference Interval
Effective August 17, 2015
Drugs CoveredCutoff Concentrations
Fentanyl0.1 ng/mL
Norfentanyl0.1 ng/mL

Interpretive Data
Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Positive cutoff:
0.1 ng/mL

For medical purposes only; not valid for forensic use.

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
CPT Code(s)
Components
Component Test Code*Component Chart NameLOINC
2011777Fentanyl, S/P, Quant3636-8
2011778Fentanyl Dose4255-6
2011779Fentanyl Dose Frequency
2011780Fentanyl Route
2011781Fentanyl Type of Draw
2011782Norfentanyl, S/P, Quant11074-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Actiq
  • Duragesic
  • Durogesic
  • Fentanyl and Metabolite
  • fentanyl and norfentanyl blood levels
  • Fentore
  • Innovar
  • Instanyl
  • Ionsys
  • norfentanyl
  • Onsolis
  • pain management
  • Sublimaze