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Colon Cancer Gene Panel, Somatic
2011616
Ordering Recommendation

Indicated for individuals with metastatic colorectal cancer to guide treatment with anti-EGFR monoclonal antibodies (ie, cetuximab and panitumumab). Detects mutations in BRAF, KRAS, NRAS, extended KRAS, and PIK3CA.

Mnemonic
CRC MASS
Methodology
Mass Spectrometry
Performed
DNA Extraction: Sun-Sat
Assay: Tue, Thu
Reported
7-10 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Tissue Tumor, Tissue Resections, or Tissue Small Biopsies. 
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat.
Transport block and/or slides in a tissue transport kit (ARUP supply #47808) available online through
eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.
Resections:
8 unstained 5-micron slides. (Min: 5 slides)
Small biopsies
: 15 unstained 5-micron slides. (Min: 10 slides) 
Storage/Transport Temperature
Room temperature. Ship in cooled container during summer months. 
Unacceptable Conditions
Less than 10 percent tumor. Specimens fixed/processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives. Decalcified specimens. 
Remarks
Include surgical pathology report. 
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable 
Reference Interval
Interpretive Data
Refer to report.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
This panel will detect hot spot mutations in KRAS, BRAF, PIK3CA and NRAS genes.
CPT Code(s)
88381; 81210 (BRAF); 81275 (KRAS); 81276 (KRAS); 81311 (NRAS); 81404 (PIK3CA)
Components
Component Test Code*Component Chart NameLOINC
2002148Block ID57723-9
2011617BRAF CRC
2011619KRAS CRC
2011620NRAS CRC
2011621PIK3CA CRC
2011875Result Summary
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Sequenom