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Caffeine, Serum or Plasma
2011603
Ordering Recommendation

Therapeutic monitoring for patients receiving caffeine therapy.

Mnemonic
CAFFEINE S
Methodology
Quantitative Enzyme Multiplied Immunoassay Technique
Performed
Wed, Sat
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum Random or Plasma Random in Plain Red, Lavender (K2EDTA), Lavender (K3EDTA), or Pink (K2EDTA). 
Specimen Preparation
Separate from cells ASAP or within 6 hours of collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.2 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Citrated Plasma, Serum separator tube (SST) 
Remarks
Please indicate in the supplied fields:
1.  Dose - List drug amount and include the units of measure
2.  Route - List the route of administration (IV, oral, etc.)
3.  Dose Frequency - Indicate how often the dose is administered (per day, per week, as needed, etc.)
4.  Type of Draw - Indicate the type of blood draw (Peak, Trough, Random, etc.) 
Stability
Ambient: 1 week; Refrigerated: 1 week; Frozen: 2 months 
Reference Interval
Effective February 21, 2017
Age0-28 days29 days and older
Therapeutic Range:8-20 µg/mLLess than or equal to 20 (not well established)
Toxic:Greater than 20 µg/mLGreater than 20 µg/mL

Interpretive Data
Toxic concentrations may cause tremor, cardiac abnormalities and seizures.

Note
CPT Code(s)
80155
Components
Component Test Code*Component Chart NameLOINC
2011604Caffeine Dose4150-9
2011605Caffeine Dose Frequency52810-9
2011606Caffeine Route45373-8
2011607Caffeine Type of Draw49049-0
2011608Caffeine, Serum or Plasma3422-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Caffeine Citrate Injection
  • Durvitan
  • NoDoz
  • Vivarin