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Copper, Random Urine
2011480
Ordering Recommendation

Useful in the assessment of overload.

Mnemonic
U COP RAND
Methodology
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Performed
Sun-Sat
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). Collection from patients receiving iodinated or gadolinium-based contrast media must be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post contrast media exposure. 
Collect
Random urine. 
Specimen Preparation
Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116), available online through eSupply using ARUP Connect or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL) 
Storage/Transport Temperature
Refrigerated. Also acceptable: Room temperature or frozen. 
Unacceptable Conditions
Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media. Acid preserved urine. Specimens transported in containers other than specified. Specimens contaminated with blood or fecal material. 
Remarks
 
Stability
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year 
Reference Interval
Effective November 13,2017
Components
Reference Interval
Copper, Urine0.3-3.2 µg/dL
Copper Urine - ratio to CRT10.0-45.0 µg/gCRT

Interpretive Data
Individuals with symptomatic Wilson disease usually excrete more than 100 g copper per day. Other conditions associated with elevated urine copper include cholestatic liver disease, proteinuria, some medications, and contaminated specimens.
Although random specimens may contain diagnostic information, 24-hour collection is a more consistent indicator of elevated copper.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Refer to Copper-Ceruloplasmin Index (Copper Free) (ARUP test code 0025079) for Wilson disease screening test. High concentrations of iodine or gadolinium may interfere with elemental testing.
Hotline History
View Hotline History
Components
Component Test Code*Component Chart NameLOINC
0020100Copper, Urine - per volume5632-5
0020207Creatinine, Urine - per volume2161-8
0025064Copper, Urine - ratio to CRT13829-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 24-hour urine copper
  • Copper/Creatinine Ratio, Urine
  • Cu
  • CUU
  • Normalized Urine Copper
  • Normalized Urine Cu