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HIV-1 Co-Receptor Tropism by Next Generation Sequencing (DEEPGEN)
2011283
Ordering Recommendation

HIV-1 sequencing test identifies tropism (CCR5 or CXCR4) of HIV-1 virus in patients being considered for CCR5 or CSCR4 antagonist therapy. If patients viral load is <1,000 HIV-1 copies/mL, refer to Trofile DNA Co-Receptor Tropism Assay (2004747).

Mnemonic
HIVDEEPGNT
Methodology
Massively Parallel Sequencing
Performed
Varies
Reported
15-18 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lavender (EDTA). Also acceptable: Plasma separator tube (PST). 
Specimen Preparation
Specimens collected in lavender (EDTA) must be separated from cells within 6 hours of collection. Specimens collected in plasma separator tube (PST) must be separated from cells within 2 hours of collection. Transfer 5 mL plasma to ARUP Standard Transport Tubes and freeze immediately. (Min: 1 mL) 
Storage/Transport Temperature
Critical Frozen: Separate specimens must be submitted with multiple tests are ordered. 
Unacceptable Conditions
 
Remarks
 
Stability
Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: Indefinitely 
Reference Interval
By Report
Interpretive Data


Note
Provide patient's most recent viral load with date of collection. This test should be used for patients with documented HIV-1 infection and a viral load greater than 1000 copies/mL.
Components
Component Test Code*Component Chart NameLOINC
2011280DEEPGEN Viral Load
2011281DEEPGEN Viral Load Date
2011284EER HIV-1 Co-Receptor Tropism by NGS11526-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases

Performed at University Hospital Translational Lab (UHTL)