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Helicobacter pylori Breath Test, Adult
2010476
Ordering Recommendation

Use to diagnose H. pylori infection in adults (>17 years of age). For children and adolescents, refer to Helicobacter pylori Breath Test, Pediatric (2010925).

Mnemonic
UBIT
Methodology
Qualitative Spectrophotometry
Performed
Sun-Sat
Reported
Within 4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
This test requires the adult patient (>17 years of age) to fast and abstain from smoking for 1 hour prior to test administration. The patient should not have taken antibiotics, proton pump inhibitors (e.g., Prilosec, Prevacid, Aciphex, Nexium), or bismuth preparations (e.g., Pepto-Bismol) within the previous 14 days. When used to monitor treatment, the test should be performed four weeks after cessation of definitive therapy. The patient should be informed that the Pranactin-Citric drink that will be administered contains phenylalanine. Phenylketonurics restrict dietary phenylalanine. 
Collect
BreathTek UBT Kit (ARUP Supply #51124 ) available online through eSupply using ARUP Connect™ or contact ARUPClient Services at (800) 522-2787. 
Specimen Preparation
1) Label breath collection bags with patient name, MRN, date and time of collection, and indicate Pre (blue) or Post (pink).
2) Collect the baseline (Pre) breath specimen according to the instructions in the BreathTek UBT kit.
3) After the allotted time, collect the Post breath specimen according to the instructions in the kit. 
Storage/Transport Temperature
CRITICAL ROOM TEMPERATURE. Do not freeze. 
Unacceptable Conditions
Underinflated bags. Pediatric specimens 
Remarks
For a valid result, the post breath specimen must be collected between 15 and 30 minutes after the patient drinks the Pranactin-Citric solution. 
Stability
Ambient: 1 week; Refrigerated: Unacceptable; Frozen: Unacceptable 
Reference Interval
Negative
Interpretive Data
A negative result does not rule out the possibility of H. pylori infection. If clinical signs are suggestive of H. pylori infection, retest with a new specimen or an alternate method. Known causes of false negative results include:
1. Use of antibiotics, proton pump inhibitors, and bismuth preparations during the preceding 2 weeks.
2. Administration of the breath test less than 4 weeks after completion of definitive therapy to eradicate H. pylori.
3. Premature or late collection of the post-dose specimen.

Known causes of false positive results include:
1. Patients with achlorhydria.
2. Rinsing the testing solution in the mouth, which can allow contact with urease-positive bacteria.
3. The presence of other gastric spiral organisms such as Helicobacter heilmanii.

Note
The post-dose sample must be collected between 15 and 30 minutes post-dose to prevent a false negative result.
CPT Code(s)
83013
Components
Component Test Code*Component Chart NameLOINC
0020646H. pylori Breath Test29891-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • 13C Urea Breath Test
  • H. Pylori Urea Breath Test
  • Helicobactor Breath Test
  • Pylori
  • Ulcer Breath Test
  • Urea Breath Test