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Bupropion, Serum or Plasma
2010357
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
BUPRO
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Wed, Sat
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. 
Collect
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA). 
Specimen Preparation
Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1.5 mL) 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered 
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution). 
Remarks
Submit With Order
Please indicate in the supplied fields:
1.  Dose - List drug amount and include the units of measure
2.  Route - List the route of administration (IV, oral, etc.)
3.  Dose Frequency - Indicate how often the dose is administered (per day, per week, as needed, etc.)
4.  Type of Draw - Indicate the type of blood draw (Peak, Trough, Random, etc.) 
Stability
After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month 
Reference Interval
Therapeutic Range50-100 ng/mL
Toxic LevelGreater than 400 ng/mL

Interpretive Data
The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Toxic concentrations may cause mental confusion, cardiac abnormalities and seizures. Concentrations below 25 ng/mL may have no effect. This method does not quantify the major metabolite, hydroxybupropion.

Note
CPT Code(s)
80338 (Alt code: G0480)
Components
Component Test Code*Component Chart NameLOINC
0099184Bupropion6706-6
2011442Bupropion Dose
2011443Bupropion Dose Frequency
2011444Bupropion Route
2011445Bupropion Type of Draw
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Wellbutrin{R} (Bupropion)
  • Zyban{R} (Bupropion)