Hypoglycemia Panel, Sulfonylureas Qualitative, Serum or Plasma
Ordering Recommendation

Preferred test for evaluating if etiology of hypoglycemia is sulfonylurea ingestion.

Qualitative Liquid Chromatography-Tandem Mass Spectrometry
Sun, Tue, Thu
1-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Plain red, gray (NaF/K Oxalate), green (Na Heparin), lavender (EDTA), or pink (K2EDTA). 
Specimen Preparation
Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.4 mL) 
Storage/Transport Temperature
Frozen. Also acceptable: Refrigerated. 
Unacceptable Conditions
Separator tubes. 
Ambient: 48 hours; Refrigerated: 11 days; Frozen: 3 months 
Reference Interval
Available SeparatelyDrugCutoff Concentration
NoGlyburide5 ng/mL
NoGlimepiride5 ng/mL
NoGlipizide5 ng/mL
NoRepaglinide5 ng/mL
NoNateglinide5 ng/mL
NoAcetohexamide100 ng/mL
NoChlorpropamide100 ng/mL
NoTolazamide100 ng/mL
NoTolbutamide100 ng/mL

Interpretive Data
This assay is used to evaluate hypoglycemia that may be caused from the ingestion of sulfonylurea drugs. Hypoglycemic drugs are detected (present) in this assay if the drug concentration is greater than the limit of detection (cut-off). The presence of hypoglycemic drug(s) indicates a recent ingestion.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
View Hotline History
CPT Code(s)
Component Test Code*Component Chart NameLOINC
2010293Tolbutamide, Serum/Plasma21567-3
2010294Tolazamide, Serum/Plasma21566-5
2010295Repaglinide, Serum/Plasma48328-9
2010296Nateglinide, Serum/Plasma49487-2
2010297Glyburide, Serum/Plasma48327-1
2010298Glipizide, Serum/Plasma48326-3
2010299Glimepiride, Serum/Plasma48325-5
2010300Chlorpropamide, Serum/Plasma48329-7
2010301Acetohexamide, Serum/Plasma43626-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Amaryl (Glimepiride)
  • Diabinese (Chlorpropamide)
  • Diabinese{R} (Sulfonylurea Hypoglycemics Panel (Qualitative), Serum or Plasma)
  • Dymelor (Acetohexamide)
  • Glucotrol (Glipizide)
  • Meglitinides
  • Micronase (Glyburide)
  • Orinase (Tolbutamide)
  • Prandin (Regaglinide)
  • Starlix (Nateglinide)
  • Tolinase (Tolazamide)