MYD88 L265P Mutation Detection by PCR, Quantitative
Ordering Recommendation
• Useful in distinguishing lymphoplasmacytic lymphoma (LPL) from other low-grade B-cell lymphoproliferative disorders which may be in the differential diagnosis.
• Use when monitoring patients with LPL diagnosis and previously identified MYD88 L265P mutation.
Submit With Order
Real-time Polymerase Chain Reaction
DNA isolation: Sun-Sat
Testing: Varies
7-10 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Lavender (EDTA) OR bone marrow (EDTA) OR tissue.  
Specimen Preparation
Whole Blood: Transport 5 mL (Min: 1 mL)
Bone marrow:
Transport 3 mL (Min: 1 mL)
FFPE tumor tissue:
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue in a tissue transport kit (ARUP Supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.  
Storage/Transport Temperature
Whole blood OR Bone marrow: Refrigerated.
FFPE tumor tissue:
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.  
Unacceptable Conditions
Serum or plasma. Specimens collected in anticoagulants other than EDTA. Clotted or severely hemolyzed specimens.
FFPE tumor tissue:
Specimens fixed/processed in alternative fixatives or heavy metal fixatives (B-4 or B-5) or tissue sections on slides. Decalcified specimens.  
Whole blood OR Bone marrow: Ambient: 24 hours; Refrigerated: 5 days; Frozen: Unacceptable
FFPE tumor tissue:
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
Interpretive Data
Refer to report.

See Compliance Statement B:
CPT Code(s)
Component Test Code*Component Chart Name
2009319MYD88 Source
2009320MYD88 L265P Detection, Result
2009321MYD88 L265P Detection, Quant
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • Lymphoplasmacytic lymphoma
  • Waldenstrom macroglobulinemia