Progesterone Quantitative by HPLC-MS/MS, Serum or Plasma
Ordering Recommendation

Aids in the workup of suspected infertility, detection of ovulation, and assessment of the luteal phase.

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Serum Separator Tube (SST). Also acceptable: Plain Red, Pink (K2EDTA), Plasma Separator Tube (PST), Green (Sodium Heparin), or Green (Lithium Heparin). 
Specimen Preparation
Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.3 mL) 
Storage/Transport Temperature
Refrigerated. Also acceptable: Frozen. 
Unacceptable Conditions
Grossly hemolyzed specimens. 
After separation from cells: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 6 months. 
Reference Interval
Effective May 16, 2016
Less than 1 yearNot Established
1-16 yearsLess than or equal to 0.15 ng/mL
17 years and olderLess than or equal to 0.11 ng/mL

Less than 1 yearNot Established
1-10 yearsLess than or equal to 0.26 ng/mL
11 yearsLess than or equal to 2.55 ng/mL
12 yearsLess than or equal to 8.56 ng/mL
13 yearsLess than or equal to 6.93 ng/mL
14 yearsLess than or equal to 12.04 ng/mL
15 yearsLess than or equal to 10.76 ng/mL
16 yearsLess than or equal to 12.94 ng/mL
17 years and olderBased on Cycle Days
1-6 daysLess than or equal to 0.17 ng/mL
7-12 daysLess than or equal to 1.35 ng/mL
13-15 daysLess than or equal to 15.63 ng/mL
16-28 daysLess than or equal to 25.55 ng/mL
Post-MenopausalLess than or equal to 0.10 ng/mL
Pregnancy, First Trimester6.25 - 45.46 ng/mL
Pregnancy, Second Trimester15.40 - 52.10 ng/mL
Pregnancy, Third Trimester24.99 - 99.92 ng/mL

Interpretive Data

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
Component Test Code*Component Chart NameLOINC
2008510Progesterone, HPLC-MS/MS2839-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • P4