ROS1 with Interpretation by Immunohistochemistry with Reflex to FISH if Equivocal
Ordering Recommendation
Determine eligibility for tyrosine kinase inhibitor (TKI) (eg, crizotinib) therapy, primarily in individuals with pulmonary adenocarcinomas.
1-5 days
Reflexed: Add 5-8 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Additional Technical InformationAdditional Technical Information

Immunohistochemistry Stain Form Recommended  (ARUP form #32978)Immunohistochemistry Stain Form Recommended (ARUP form #32978)

Specimen Required
Patient Preparation
Tumor tissue  
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Transport tissue block or 6 unstained (3- to 5-micron thick sections), positively charged slides in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect or contact ARUP Client Services at (800)522-2787. (Min: 6 slides) If sending precut slides, do not oven bake.  
Storage/Transport Temperature
Room temperature or refrigerated. Ship in cooled container during summer months.  
Unacceptable Conditions
Paraffin block with no tumor tissue remaining. Specimens fixed in any other fixative other than 10 percent neutral buffered formalin. Cytology specimens fixed in alcohol. Decalcified specimens.  
Include pathology report. IMMUNOHISTOCHEMISTRY ORDERING AND SUBMISSION DETAILS: Submit electronic request. If you do not have electronic ordering capability, use an ARUP Immunohistochemistry form (#32978) with an ARUP client number. For additional technical details, please contact ARUP Client Services at (800) 522-2787.  
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
Interpretive Data
Refer to report.  
If ROS1by Immunohistochemistry result is equivocal, then ROS1 by FISH will be added. Additional charges apply.
CPT Code(s)
88360, if reflexed, add 88366
Component Test Code*Component Chart NameLOINC
2008415ROS1 by IHC Result 
2008417ROS1 Client Block ID 
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • ROS1 IHC
  • ROS1 IHC with Interpretation
  • ROS1 immunostaining