Human Papillomavirus (HPV), High Risk by Hybrid Capture, ThinPrep
2008404
Ordering Recommendation
Adjunct to cytology (Pap smear) for cervical cancer screening and monitoring.
Mnemonic
TP HPVHI
Methodology
Qualitative Nucleic Acid Probe
Performed
Sun-Sat
Reported
1-5 days  
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Submit With Order
Specimen Required
Patient Preparation
Females should avoid high concentrations of antifungal cream, contraceptive jelly, or douche at time of collection.  
Collect
Cervical Brush in ThinPrep transport media.  
Specimen Preparation
Place each specimen in an individually sealed bag. (Min: 4 mL)  
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated.  
Unacceptable Conditions
Specimens in any transport media other than indicated above. For specimens in SurePath transport media, refer to ARUP test code 0060744. For cervical brush specimens in Digene transport media, refer to ARUP test code 0065999. For ThinPrep specimens of less than 4 mL, refer to ARUP test code 2007893.  
Remarks
Specimen source required.  
Stability
Ambient: 3 months; Refrigerated: 3 months; Frozen: Unacceptable  
Reference Interval
Negative  
Interpretive Data
This test detects high-risk HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68 associated with cervical cancer and its precursor lesions. However, cross-reactions with other genotypes may occur. Results should be correlated with cytologic and histologic findings. Sensitivity may be affected by specimen cellularity.

This test is intended for medical purposes only and is not valid for the evaluation of suspected sexual abuse or for other forensic purposes.

HPV testing should not be used for screening or management of atypical squamous cells of undetermined significance (ASCUS) in women under age 21.  
Note
For information regarding the comparison of HPV TMA and HPV Hybrid Capture assays, refer to this educational video: <http://arup.utah.edu/education/shortTopics/spot_FDAhpv.php>.
CPT Code(s)
87621
Components
Component Test Code*Component Chart Name
0060752HPV Source
2008405HPV High Risk, Hybrid Capture, ThinPrep
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • HPV HR ThinPrep
  • HPV RNA, High Risk, E6/E7, TMA (Human Papillomavirus (HPV) DNA Probe, High Risk (ThinPrep)