Celiac Disease Reflexive Cascade
2008114
Ordering Recommendation
Preferred reflex screening test for celiac disease. May aid in monitoring adherence to gluten-free diet.
Mnemonic
CELIAC REF
Methodology
Quantitative Nephelometry/Semi-Quantitative Enzyme-Linked Immunosorbent Assay//Semi-Quantitative Indirect Fluorescent Antibody
Performed
Sun-Sat
Reported
2-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
- Patient Preparation
- Collect
- Serum separator tube.
- Specimen Preparation
- Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL)
- Storage/Transport Temperature
- Refrigerated.
- Unacceptable Conditions
- Plasma. Contaminated, hemolyzed, grossly icteric or grossly lipemic specimens.
- Remarks
- Stability
- After separation from cells: Ambient: 8 hours; Refrigerated: 8 days; Frozen: 1 year (if frozen within 24 hours)
Reference Interval
Effective February 16, 2016
Test Number | Components | Reference Interval | ||||||
---|---|---|---|---|---|---|---|---|
0050340 | Immunoglobulin A | Effective February 16, 2016
| ||||||
0051689 | Celiac Disease Dual Antigen Screen |
| ||||||
0051357 | Deamidated Gliadin Peptide (DGP) Antibody, IgA |
| ||||||
0051359 | Deamidated Gliadin Peptide (DGP) Antibody, IgG |
| ||||||
0097709 | Tissue Transglutaminase (tTG) Antibody, IgA |
| ||||||
0050736 | Endomysial Antibody, IgA by IFA | Less than 1:10 | ||||||
0056009 | Tissue Transglutaminase Antibody, IgG |
|
Interpretive Data
Refer to report.
Note
The Celiac Disease Reflexive Cascade begins with Immunoglobulin A. Depending on findings, one or more reflexive tests may be required in order to provide a clinical interpretation. Tests added may include Tissue Transglutaminase Antibody, IgA; Tissue Transglutaminase Antibody, IgG; Endomysial Antibody, IgA by IFA; Deamidated Gliadin Peptide (DGP) Antibody, IgA; Deamidated Glaidin Peptide (DGP) Antibody, IgG; and/or Celiac Disease Dual Antigen Screen. Refer to the Celiac Testing Algorithm found at http://www.arupconsult.com/Algorithms/CeliacDz.pdf. Additional charges apply.
Hotline History
N/A
CPT Code(s)
82784; if reflexed additional CPT codes may apply: 83516, 83516 x2 and/or 86256.
add 83516; if reflexed to tTG IgA and Gliadin IgA, add 83516 x 2; if reflexed to tTG IgG and Gliadin IgG, add 83516 x2.; if IgA is greater than or equal to the normal age range, add 83516; if reflexed, add 86256 and 83516.
add 83516; if reflexed to tTG IgA and Gliadin IgA, add 83516 x 2; if reflexed to tTG IgG and Gliadin IgG, add 83516 x2.; if IgA is greater than or equal to the normal age range, add 83516; if reflexed, add 86256 and 83516.
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050340 | Immunoglobulin A | 2458-8 |
Aliases