Motor and Sensory Neuropathy Evaluation with Immunofixation Electrophoresis and Reflex to Titer and Neuronal Immunoblot
2007967
Ordering Recommendation
Aid in diagnosis of combined motor/sensory neuropathy when plasma cell dyscrasia or other malignancy is suspected.
Mnemonic
MSNCR
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot/Quantitative Nephelometry/Quantitative Capillary Electrophoresis/Qualitative Immunofixation Electrophoresis
Performed
Refer to individual components
Reported
3-9 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
- Patient Preparation
- Collect
- Serum separator tube
- Specimen Preparation
- Separate serum from cells ASAP or within 2 hours of collection. Transfer 4 mL serum to an ARUP Standard Transport Tube. (Min: 2 mL)
- Storage/Transport Temperature
- Refrigerated
- Unacceptable Conditions
- Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, hemolyzed, severely icteric, or lipemic specimens.
- Remarks
- Stability
- Ambient: Unacceptable; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval
Effective February 16, 2016
Test Number | Components | Reference Interval | ||
---|---|---|---|---|
Purkinje Cell/Neuronal Nuclear IgG Scrn | None Detected | |||
Neuronal Nuclear Antibody (ANNA) IFA Titer, IgG | Less than 1:10 | |||
Purkinje Cell Antibody, Titer | Less than 1:10 | |||
2007963 | Neuronal Nuclear Antibodies (Hu, Ri, Yo) IgG by Immunoblot | None Detected | ||
0051285 | Myelin Associated Glycoprotein (MAG) Antibody, IgM | Less than 1000 TU | ||
0051284 | Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgM | Less than 1.00 IV | ||
Asialo-GM1 Antibodies, IgG/IgM | 29 IV or less: Negative 30-50 IV: Equivocal 51-100 IV: Positive 101 IV or greater: Strong Positive | |||
GM1 Antibodies, IgG/IgM | 29 IV or less: Negative 30-50 IV: Equivocal 51-100 IV: Positive 101 IV or greater: Strong Positive | |||
GD1a Antibodies, IgG/IgM | 29 IV or less: Negative 30-50 IV: Equivocal 51-100 IV: Positive 101 IV or greater: Strong Positive | |||
GD1b Antibodies, IgG/IgM | 29 IV or less: Negative 30-50 IV: Equivocal 51-100 IV: Positive 101 IV or greater: Strong Positive | |||
GQ1b Antibodies, IgG/IgM | 29 IV or less: Negative 30-50 IV: Equivocal 51-100 IV: Positive 101 IV or greater: Strong Positive | |||
Total Protein-Electrophoresis, Serum | 6.00-8.30 g/dL | |||
Albumin | 3.75-5.01 g/dL | |||
Alpha-1 Globulins | 0.19-0.46 g/dL | |||
Alpha-2 Globulins | 0.48-1.05 g/dL | |||
Beta Globulins | 0.48-1.10 g/dL | |||
Gamma | 0.62-1.51 g/dL | |||
0050340 | Immunoglobulin A | Effective February 16, 2016
| ||
0050350 | Immunoglobulin G |
| ||
0050355 | Immunoglobulin M | Effective February 16, 2016
|
Test Number | Components | Reference Interval | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
  | Albumin | 3.75-5.01 g/dL | |||||||||||||||
  | Alpha 1 Globulin | 0.19-0.46 g/dL | |||||||||||||||
  | Alpha 2 Globulin | 0.48-1.05 g/dL | |||||||||||||||
  | Beta Globulin | 0.48-1.10 g/dL | |||||||||||||||
  | Gamma | 0.62-1.51 g/dL | |||||||||||||||
0050340 | Immunoglobulin A | Effective February 16, 2016
| |||||||||||||||
0050350 | Immunoglobulin G |
| |||||||||||||||
0050355 | Immunoglobulin M | Effective February 16, 2016
| |||||||||||||||
  | Total Protein-Electrophoresis | 6.00-8.30 g/dL | |||||||||||||||
  | Asialo-GM1 Antibodies, IgG/IgM |
| |||||||||||||||
  | GM1 Antibodies, IgG/IgM |
| |||||||||||||||
  | GD1a Antibodies, IgG/IgM |
| |||||||||||||||
  | GD1b Antibodies, IgG/IgM |
| |||||||||||||||
  | GQ1b Antibodies, IgG/IgM |
| |||||||||||||||
0051284 | Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgM | Less than 1.00 IV | |||||||||||||||
0051285 | Myelin Associated Glycoprotein (MAG) Antibody, IgM | Less than 1000 TU | |||||||||||||||
2007961 | Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot |
| |||||||||||||||
2007963 | Neuronal Nuclear Antibodies (Hu, Ri, Yo) IgG by Immunoblot | None Detected | |||||||||||||||
Interpretive Data
Compliance Statement D: For laboratory tests using a manufactured RUO kit. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
Note
Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, and Yo) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, and Yo) IgG by Immunoblot will be added. Additional charges apply.
Hotline History
View Hotline History
CPT Code(s)
83516 x7; 84160; 82784 x3; 84165; 86334; 86255; if reflexed add 83516 and/or 86256
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050020 | Albumin | 2862-1 |
0050035 | Alpha 1 Globulin | 2865-4 |
0050060 | Alpha 2 Globulin | 2868-8 |
0050110 | Beta Globulin | 2871-2 |
0050270 | Gamma | 2874-6 |
0050271 | Immunofixation | 25700-6 |
0050340 | Immunoglobulin A | 2458-8 |
0050350 | Immunoglobulin G | 2465-3 |
0050355 | Immunoglobulin M | 2472-9 |
0050545 | Total Protein-Electrophoresis | 2885-2 |
0051034 | Asialo-GM1 Antibodies, IgG/IgM | 88723-2 |
0051035 | GM1 Antibodies, IgG/IgM | 31500-2 |
0051037 | GD1a Antibodies, IgG/IgM | 88724-0 |
0051038 | GD1b Antibodies, IgG/IgM | 88730-7 |
0051039 | GQ1b Antibodies, IgG/IgM | 88729-9 |
0051284 | SGPG Antibody, IgM | 31666-1 |
0051285 | MAG Antibody, IgM Elisa | 17314-6 |
2005168 | SPEP/IFE Interpretation | 49275-1 |
2007962 | Purkinje Cell/Neuronal Nuclear IgG Scrn | 61177-2 |
2012458 | EER Motor Sensory Neuropathy Comp |
Aliases