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Motor and Sensory Neuropathy Evaluation with Reflex to Titer and Neuronal Immunoblot (Testing Alert as of 03/17/18: Refer to Note for details)
2007966
Ordering Recommendation

Aid in diagnosis of combined motor/sensory neuropathy when malignancy, other than plasma cell dyscrasia, is suspected.

Mnemonic
MSNER
Methodology
Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody/Qualitative Immunoblot
Performed
Thu
Reported
1-9 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube 
Specimen Preparation
Separate serum from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) 
Storage/Transport Temperature
Refrigerated 
Unacceptable Conditions
Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, hemolyzed, severely icteric, or lipemic specimens. 
Remarks
 
Stability
Ambient: Unacceptable; Refrigerated: 2 weeks; Frozen: 1 year 
Reference Interval
Test Number
Components
Reference Interval
 Asialo-GM1 Antibodies, IgG/IgM
29 IV or lessNegative
30-50 IVEquivocal
51-100 IVPositive
101 IV or greaterStrong Positive

 GM1 Antibodies, IgG/IgM
29 IV or lessNegative
30-50 IVEquivocal
51-100 IVPositive
101 IV or greaterStrong Positive

 GD1a Antibodies, IgG/IgM
29 IV or lessNegative
30-50 IVEquivocal
51-100 IVPositive
101 IV or greaterStrong Positive

 GD1b Antibodies, IgG/IgM
29 IV or lessNegative
30-50 IVEquivocal
51-100 IVPositive
101 IV or greaterStrong Positive

 GQ1b Antibodies, IgG/IgM
29 IV or lessNegative
30-50 IVEquivocal
51-100 IVPositive
101 IV or greaterStrong Positive

0051284Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgMLess than 1.00 IV
0051285Myelin Associated Glycoprotein (MAG) Antibody, IgMLess than 1000 TU
2007961Paraneoplastic Antibodies (PCCA/ANNA) by IFA with Reflex to Titer and Immunoblot
Test Number
Components
Reference Interval
Purkinje Cell/Neuronal Nuclear IgG ScrnNone Detected
Neuronal Nuclear Antibody (ANNA) IFA Titer, IgGLess than 1:10
Purkinje Cell Antibody, TiterLess than 1:10
2007963Neuronal Nuclear Antibodies (Hu, Ri, Yo) IgG by ImmunoblotRefer to report


Interpretive Data


Compliance Statement D: For laboratory tests using a manufactured RUO kit. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
The Asialo-GM1 Antibodies, IgG/IgM component of this test is unavailable due to a nationwide manufacturer reagent issue. The result of this individual component alone has minimal clinical significance but can support an overall clinical diagnosis in conjunction with other clinical parameters and/or other motor neuropathy markers. The other panel components are not affected by this reagent issue and will be reported within the published turn-around time.

Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, and Yo) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, and Yo) IgG by Immunoblot will be added. Additional charges apply.
Hotline History
N/A
CPT Code(s)
83516 x 6; 86255; if reflexed add 83516 and/or 86256
Components
Component Test Code*Component Chart NameLOINC
0051034Asialo-GM1 Antibodies, IgG/IgM44737-5
0051035GM1 Antibodies, IgG/IgM63244-8
0051037GD1a Antibodies, IgG/IgM48656-3
0051038GD1b Antibodies, IgG/IgM26870-6
0051039GQ1b Antibodies, IgG/IgM31674-5
0051284SGPG Antibody, IgM31666-1
0051285MAG Antibody, IgM Elisa17314-6
2007962Purkinje Cell/Neuronal Nuclear IgG Scrn61177-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases