Venlafaxine and Metabolite, Serum or Plasma
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Sun, Wed
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
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ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Pre-dose (trough) draw - At steady state concentration. 
Lavender (EDTA), pink (K2EDTA) or plain red. 
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD Solution). 
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Please indicate in the supplied fields:
1.  Dose - List drug amount and include the units of measure
2.  Route - List the route of administration (IV, oral, etc.)
3.  Dose Frequency - Indicate how often the dose is administered (per day, per week, as needed, etc.)
4.  Type of Draw - Indicate the type of blood draw (Peak, Trough, Random, etc.) 
Ambient: 2 weeks; Refrigerated: 2 weeks; Frozen: 2 weeks 
Reference Interval
Therapeutic range - Total (venlafaxine and o-desmethylvenlafaxine)195-400 ng/mL
Toxic rangeNot well established

Interpretive Data
The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Adverse effects to venlafaxine therapy may include nausea, vomiting, dizziness, tremor and blurred vision.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
CPT Code(s)
Component Test Code*Component Chart NameLOINC
2007958Venlafaxine Serum/Plasma9630-5
2007959O-Desmethylvenlafaxine Serum/Plasma9628-9
2007960Total Venlafaxine and Metabolite S/P62849-5
2011589Venlafaxine Dose65818-7
2011590Venlafaxine Dose Frequency52810-9
2011591Venlafaxine Route45373-8
2011592Venlafaxine Type of Draw49049-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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