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Tricyclic Antidepressants, Quantitative, Serum or Plasma
2007549
Ordering Recommendation

Optimize drug therapy and monitor patient adherence.

Mnemonic
TADQNT SP
Methodology
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Mon, Wed, Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Timing of specimen collection: Pre-dose (trough) draw - At steady-state concentration. 
Collect
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA). 
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution). 
Remarks
 
Stability
After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months 
Reference Interval
Effective November 18th, 2013
Drug
Therapeutic Range
Toxic
Amitriptyline (Elavil, Vanatrip)Not establishedNot established
Nortriptyline (Aventyl, Pamelor)50-150 ng/mLGreater than 500 ng/mL
Total Amitriptyline + Nortriptyline95-250 ng/mLGreater than 500 ng/mL
Imipramine (Tofranil)Not establishedNot established
Desipramine (Norpramin)100-300 ng/mLGreater than 500 ng/mL
Total Imipramine + Desipramine150-300 ng/mLGreater than 500 ng/mL
Doxepin (Sinequan, Zonalon)Not establishedNot established
NordoxepinNot establishedNot established
Total Doxepin + Nordoxepin100-300 ng/mLGreater than 500 ng/mL
Protriptyline (Vivactil)70-240 ng/mLGreater than 400 ng/mL
Clomipramine (Anafranil)Not establishedNot established
NorclomipramineNot establishedNot established
Total Clomipramine + Norclomipramine220-500 ng/mLGreater than 900 ng/mL

Interpretive Data


Note
This test is used to quantitate the following tricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepin, imipramine, norclomipramine, nordoxepin, nortriptyline, and protriptyline.
CPT Code(s)
Components
Component Test Code*Component Chart NameLOINC
0090020Amitriptyline/Nortriptyline, Total, SP3335-7
0090024Amitriptyline, SP3333-2
0090065Desipramine, SP3531-1
0090100Doxepin, SP3579-0
0090101Doxepin/Nordoxepin Total, SP3582-4
0090105Nordoxepin, SP3862-0
0090106Protriptyline, SP3999-0
0090135Imipramine/Desipramine Total, SP9627-1
0090139Imipramine, SP3690-5
0090210Nortriptyline, SP3872-9
0099320Clomipramine/Norclomipramine, Total, SP3493-4
0099335Norclomipramine, SP3536-0
0099437Clomipramine (Anafranil), SP3491-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Tricyclic Antidepressant Screen
  • Tricyclic Screen