Tricyclic Antidepressants, Quantitative, Urine
Ordering Recommendation

Preferred test to follow-up presumptive results or for monitoring compliance. To optimize drug therapy, Tricyclic Antidepressants, Quantitative, Serum or Plasma (2007549) is preferred.

Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Tue, Thu, Sat
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Random urine. 
Specimen Preparation
Transfer 2 mL urine to ARUP Standard Transport Tube. (Min: 0.7 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Ambient: 1 week; Refrigerated: 11 days; Frozen: 2 weeks 
Reference Interval

Interpretive Data
Interpretive Data: Interpretive comments: Urine concentrations of tricyclic antidepressants do not correlate with signs or symptoms of therapy or toxicity.
Therapeutic ranges are not established.
100 ng/mL limit of quantification: Amitriptyline, Nortriptyline, Imipramine, Desipramine, Doxepin, Nordoxepin, Protriptyline
200 ng/mL limit of quantification: Clomipramine, Norclomipramine

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

This test is used to quantitate the following tricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepin, imipramine, norclomipramine, nordoxepin, nortriptyline and protriptyline.
Hotline History
CPT Code(s)
Component Test Code*Component Chart NameLOINC
2007516Amitriptyline, Quant, Urn16114-1
2007517Nortriptyline, Quant, Urn3875-2
2007518Amitriptyline/Nortriptyline Total, Urn10978-5
2007519Imipramine Quant, Urn3692-1
2007520Desipramine Quant, Urn3534-5
2007521Imipramine/Desipramine Total, Urn
2007522Doxepin Quant, Urn3581-6
2007523Nordoxepin Quant, Urn12386-9
2007524Doxepin/Nordoxepin Total, Urn19247-6
2007525Protriptyline Quant, Urn26978-7
2007526Clomipramine Quant, Urn3492-6
2007527Norclomipramine Quant, Urn18470-5
2007528Clomipramine/Norclomipramine Total, Urn
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Quantitative Antidepressant Drug Screen
  • TCA Screen
  • Tricyclic Screen