EWSR1 (22q12) Gene Rearrangement by FISH
2007225
Ordering Recommendation
Diagnose members of the Ewing sarcoma family of tumors (ESFT); however, this assay does not identify the translocation partner.
Submit With Order
Mnemonic
EWSR1 FISH
Methodology
Fluorescence in situ Hybridization
Performed
Varies
Reported
4-12 days
New York DOH Approval Status
Specimens from New York clients will be sent out to a New York DOH approved laboratory, if possible.
Specimen Required
Patient Preparation
 
Collect
Tumor tissue.  
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Transport tissue block or 6 unstained 5-micron slides. (Min: 3 slides) Protect paraffin block from excessive heat. Transport block(s) and/or slide(s) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.  
Storage/Transport Temperature
Room temperature. Also acceptable: Refrigerated. Ship in cooled container during summer months.  
Unacceptable Conditions
Frozen specimens. Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.  
Remarks
Include surgical pathology report.  
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
Interpretive Data
Refer to report.

See Compliance Statement A: www.aruplab.com/CS
Note
CPT Code(s)
88367
Components
Component Test Code*Component Chart Name
0049335EWSR1 by FISH
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Cross References
  • 22q12
  • EWSR1 FISH
  • EWSR1 Gene rearrangement