Cytomegalovirus, Quantitative PCR with Reflex to Drug Resistance Testing by Sequencing
Ordering Recommendation

Detect and quantify cytomegalovirus. Determine antiviral drug resistance to cidofovir, foscarnet sodium, and ganciclovir.

Quantitative Polymerase Chain Reaction/Sequencing
4-6 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Lavender (EDTA) or pink (K2EDTA). 
Specimen Preparation
Separate plasma from cells. Transfer 4 mL plasma to a sterile container. (Min: 2.5 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Serum. Heparinized specimens. 
Ambient: 8 hours; Refrigerated: 72 hours; Frozen: 1 year 
Reference Interval
Not detected
Interpretive Data
The quantitative range of this test is 2.6-6.6 log copies/mL (390-3,900,000 copies/mL) or 2.4-6.4 log IU/mL (227-2,270,000 IU/mL). One IU/mL of CMV DNA is approximately 1.72 copies/mL.

A negative result (less than 2.6 log copies/mL [less than 390 copies/mL] OR less than 2.4 log IU/mL [less than 227 IU/mL]) does not rule out the presence of PCR inhibitors in the patient specimen or CMV DNA concentrations below the level of detection of the test. Inhibition may also lead to underestimation of viral quantitation.

Compliance Statement A: Analyte specific reagents (ASR) are used in many laboratory tests necessary for standard medical care and generally do not require U.S. Food and Drug Administration (FDA) approval or clearance. This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions. This test should not be regarded as investigational or for research use.

If CMV Quantitative PCR result is greater than or equal to 3.2 log (1600 copies/mL), then CMV Antiviral Drug Resistance by Sequencing will be added. Additional charges apply.
CPT Code(s)
Component Test Code*Component Chart NameLOINC
0051814Cytomegalovirus Quant by PCR, Interp40444-2
0051815Cytomegalovirus Quant by PCR, Log Cpy/mL54206-8
2002316Cytomegalovirus Quant by PCR, Cpy/mL30247-1
2006534Cytomegalovirus Quant by PCR, IU/mL72493-0
2006535Cytomegalovirus Quant by PCR, Log IU/mL72494-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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