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Drug Detection Panel, Umbilical Cord Tissue, Qualitative
2006621
Ordering Recommendation

Detect and document maternal drug use during approximately the last trimester of a full term birth.

Mnemonic
TOF SCR CD
Methodology
Qualitative Liquid Chromatography/Tandem Mass Spectrometry/Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-3 days
N/A
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
 
Collect
at least 6 inches of umbilical cord (approximately the length of an adult hand). 
Specimen Preparation
Drain and discard any blood. Rinse the exterior of the cord segment with normal saline or sterile water. Pat the cord dry and transfer specimens to the appropriate transport device or use the Security Kit for Meconium/Umbilical Drug Detection (ARUP supply #51548) available online through eSupply using ARUP Connect™ or by contacting ARUP Client Services at (800) 522-2787. 
Storage/Transport Temperature
Refrigerated. 
Unacceptable Conditions
Cords soaking in blood or other fluid. Formalin fixed. Tissue that is obviously decomposed. 
Remarks
 
Stability
Ambient, 1 week; Refrigerated, 3 weeks; Frozen, 1 year 
Reference Interval
Effective May 16, 2016
Drugs covered and range of cutoff concentrations.
Drugs/Drug Classes
Cutoff Concentrations (ng/g)
Drugs/Drug Classes
Cutoff Concentrations (ng/g)
Buprenorphine1Amphetamine5
Norbuprenorphine0.5Benzoylecgonine0.5
Buprenorphine-G1m-OH-Benzoylecgonine1
Codeine0.5Cocaethylene1
Dihydrocodeine1Cocaine0.5
Fentanyl0.5MDMA (Ecstasy)5
Hydrocodone0.5Methamphetamine5
Norhydrocodone1Phentermine8
Hydromorphone0.5Alprazolam0.5
Meperidine2Alpha-OH-Alprazolam0.5
Methadone2Butalbital25
Methadone metabolite1Clonazepam1
6-Acetylmorphine17-Aminoclonazepam1
Morphine0.5Diazepam1
Naloxone1Lorazepam5
Oxycodone0.5Midazolam1
Noroxycodone1Alpha-OH-Midazolam2
Oxymorphone0.5Nordiazepam1
Noroxymorphone0.5Oxazepam2
Propoxyphene1Phenobarbital75
Tapentadol2Temazepam1
Tramadol2Zolpidem0.5
N-desmethyltramadol2Phencyclidine (PCP)1
O-desmethyltramadol2Marijuana Metabolite1

Interpretive Data
Methodology: Qualitative Liquid Chromatography/Tandem Mass Spectrometry/Enzyme-Linked Immunosorbent Assay

Detection of drugs in umbilical cord tissue is intended to reflect maternal drug use during pregnancy. The pattern and frequency of drug(s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in umbilical cord tissue depends on extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in umbilical cord tissue, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory. Glucuronide metabolites are indicated as-G.

For medical purposes only; not valid for forensic use unless testing was performed within Chain of Custody process.

Compliance Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Note
Absolute Minimum:  6 inches
Components
Component Test Code*Component Chart NameLOINC
2006622Drug Detection Panel, Umbilical Cord
2006626Buprenorphine, Cord, Qual
2006627Buprenorphine-G, Cord, Qual
2006628Codeine, Cord, Qual40626-4
2006629Dihydrocodeine, Cord, Qual
2006630Fentanyl, Cord, Qual61042-8
2006631Hydrocodone, Cord, Qual32080-4
2006632Hydromorphone, Cord, Qual32081-2
2006633Meperidine, Cord, Qual32088-7
2006634Methadone, Cord, Qual32093-7
2006635Methadone Metabolite, Cord, Qual41859-0
20066366-Acetylmorphine, Cord, Qual32099-4
2006637Morphine, Cord, Qual32100-0
2006638Naloxone, Cord, Qual
2006640Oxycodone, Cord, Qual32101-8
2006641Oxymorphone, Cord, Qual
2006642Propoxyphene, Cord, Qual43811-9
2006644Tapentadol, Cord, Qual
2006645Tramadol, Cord, Qual
2006646N-desmethyltramadol, Cord, Qual
2006647O-desmethyltramadol, Cord, Qual
2006648Amphetamine, Cord, Qual29530-3
2006649Benzoylecgonine, Cord, Qual40609-0
2006650m-OH-Benzoylecgonine, Cord, Qual
2006652Cocaethylene, Cord, Qual
2006653Cocaine, Cord, Qual40625-6
2006654MDMA- Ecstasy, Cord, Qual40481-4
2006657Methamphetamine, Cord, Qual40381-6
2006658Phentermine, Cord, Qual
2006659Alprazolam, Cord, Qual61038-6
2006660Alpha-OH-Alprazolam, Cord, Qual61037-8
2006662Butalbital, Cord, Qual32057-2
2006663Clonazepam, Cord, Qual61039-4
20066647-Aminoclonazepam, Cord, Qual61031-1
2006665Diazepam, Cord, Qual61074-1
2006671Lorazepam, Cord, Qual61044-4
2006672Midazolam, Cord, Qual
2006673Alpha-OH-Midazolam, Cord, Qual
2006675Nordiazepam, Cord, Qual61051-9
2006676Oxazepam, Cord, Qual61055-0
2006677Phenobarbital, Cord, Qual32108-3
2006679Temazepam, Cord, Qual61061-8
2006682Zolpidem, Cord, Qual
2006683Phencyclidine- PCP, Cord, Qual32107-5
2008360Marijuana Metabolite, Cord, Screen43834-1
2009199EER Drug Detection Pan, Umbilical Cord11526-1
2013103Norbuprenorphine, Cord, Qual
2013104Norhydrocodone, Cord, Qual
2013105Noroxycodone, Cord, Qual
2013106Noroxymorphone, Cord, Qual
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Drug Screen, Targeted, Serum or Plasma
  • Drugs of Abuse Panel, Meconium - Screen with Reflex to Confirmation/Quantitation