BCR-ABL1, Major (p210), Quantitative
2005017
Ordering Recommendation
This quantitative test is appropriate for diagnosis and therapeutic monitoring for CML or ALL. The BCR-ABL1 major (p210) fusion forms are present in almost all cases of CML and in a small subset of cases of ALL
Mnemonic
BCR MAJ
Methodology
Quantitative Reverse Transcription Polymerase Chain Reaction
Performed
RNA isolation: Sun-Sat
Assay:
Mon, Wed-Fri
Reported
5-7 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Lavender (EDTA) or bone marrow (EDTA).  
Specimen Preparation
Transport 5 mL whole blood or 3 mL bone marrow. (Min: 1 mL whole blood or 1 mL bone marrow) Specimens must be received within 48 hours of collection due to lability of RNA.  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Serum or plasma. Specimens collected in anticoagulants other than EDTA. Severely hemolyzed specimens. Frozen or clotted specimens.  
Remarks
  
Stability
Ambient: 1 hour; Refrigerated: 48 hours; Frozen: Unacceptable  
Reference Interval
   
Interpretive Data
Refer to report.

See Compliance Statement D: www.aruplab.com/CS  
Note
This test does not detect the rare BCR-ABL1 micro (p230) fusion form.

For the p190 fusion form (minor breakpoint), order BCR-ABL1, Minor (p190), Quantitative (ARUP test code 2005016).
CPT Code(s)
81206
Components
Component Test Code*Component Chart Name
0051095BCR-ABL1, t(9;22) Source
2005012BCR-ABL1, Major (p210) Result
2005013BCR-ABL1/ABL1, Major (p210) Quant Ratio
2005014BCR-ABL1, International Scale (Percent)
2005015EER BCR-ABL1, Major (p210)
2005271BCR-ABL1 Maj Molecular Response achieved
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CML RT-PCR
  • p210
  • Philadelphia Chromosome Ph1 Bone Marrow/Blood
  • t(9;22)