BCR-ABL1, Qualitative with Reflex to BCR-ABL1 Quantitative
2005010
Ordering Recommendation
For use in detecting the presence of a BCR-ABL1 fusion, for determining breakpoint status, and for baseline quantitation.
Mnemonic
BCR RFLX
Methodology
Reverse Transcription Polymerase Chain Reaction
Performed
RNA isolation: Sun-Sat
Assay:
Sun, Tue-Fri
Reported
7-10 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Lavender (EDTA) or bone marrow (EDTA).  
Specimen Preparation
Transport 5 mL whole blood or 3 mL bone marrow. (Min: 1 mL whole blood or 1 mL bone marrow) Specimens must be received within 48 hours of collection due to lability of RNA.  
Storage/Transport Temperature
Refrigerated.  
Unacceptable Conditions
Serum or plasma. Specimens collected in anticoagulants other than EDTA. Severely hemolyzed specimens. Frozen or clotted  specimens.  
Remarks
  
Stability
Ambient: 1 hour; Refrigerated: 48 hours; Frozen: Unacceptable  
Reference Interval
   
Interpretive Data
Refer to report.

See Compliance Statement B: www.aruplab.com/CS
Statement B: This test was developed and its performance characteristics determined by ARUP Laboratories. The U.S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
 
Note
This reflex assay is recommended when the BCR-ABL1 fusion form is not known or unclear.  This reflex assay detects the presence of either the p210 (major breakpoint) or p190 (minor breakpoint).  If the presence of either the p210 or p190 BCR-ABL1 fusion is detected, then the appropriate quantitative test will be performed.

If the fusion form is known, refer to BCR-ABL1, Major (p210), Quantitative  (ARUP test code 2005017) or BCR-ABL1, Minor (p190), Quantitative (ARUP test code 2005016).
CPT Code(s)
81206; 81207; If reflexed, add 81206 or 81207
If reflexed, add 81206 or 81207
Components
Component Test Code*Component Chart NameLOINC
0055553BCR-ABL1, t(9;22) Qual by RT-PCR21821-4
2006592BCR-ABL1 Source31208-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • p190
  • p210
  • PH1
  • philadelphia chormosome
  • Philadelphia MS
  • t(9;22)