Macroamylase Determination
Ordering Recommendation
Quantitative Ultrafiltration/Quantitative Enzymatic
2-9 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Plasma separator tube, serum separator tube, or plain red. 
Specimen Preparation
Allow specimen to clot completely at room temperature. Separate serum or plasma from cells ASAP or within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1.1 mL) 
Storage/Transport Temperature
Unacceptable Conditions
Specimens containing calcium chelating anticoagulants such as citrates, EDTA, or oxalates. 
After separation from cells: Ambient: 1 week; Refrigerated: 1 month; Frozen: 1 month 
Reference Interval
Test Number
Reference Interval
 Amylase, Total
3-90 days0-30 U/L
3-6 months7-40 U/L
7-8 months7-57 U/L
9-11 months11-70 U/L
12-17 months11-79 U/L
18-35 months19-92 U/L
3-4 years26-106 U/L
5-12 years30-119 U/L
13 years and older30-110 U/L

 Amylase, Monomeric
18 years and older23-110 U/L

 Amylase, Percent MonomericGreater than or equal to 71 percent

Interpretive Data
An amylase, monomeric result above the upper reference limit is consistent with hyperamylasemia. An amylase, percent monomeric less than 71 percent suggests the presence of macroamylase.

Amylase, monomeric is determined after ultrafiltration. Macroamylase is removed by ultrafiltration and is not measured.

For confirmation of macroamylasemia, consider ordering Amylase, Urine (ARUP test code 0020471).

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.

Hotline History
Component Test Code*Component Chart NameLOINC
2004465Amylase, Total1798-8
2004466Amylase, Monomeric2591-6
2004467Amylase, Percent Monomeric26011-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Monomeric Amylase
  • monomeric and total amylase
  • serum macroamylase