Protein C, Functional with Reflex to Protein C, Total and Protein S, Free with Reflex to Protein S, Total

2003386

Ordering Recommendation

Acceptable panel to detect and subtype protein C and S deficiencies. Do not order if the individual has been on warfarin therapy in the previous 2-4 weeks.

Mnemonic

PROT C/S R

Methodology

Electromagnetic Mechanical Clot Detection/Enzyme-Linked Immunosorbent Assay/Microlatex Particle-Mediated Immunoassay

Performed

Mon-Fri

Reported

1-5 days

New York DOH Approval Status

This test is New York DOH approved.

Submit With Order

ARUP Consult®

Disease Topics

Interface Map

Specimen Required

Patient Preparation
Collect: Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Specimen Preparation: Transfer 4 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 2 mL)
Storage/Transport Temperature: CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Unacceptable Conditions: Serum. EDTA plasma, clotted or hemolyzed specimens.
Remarks
Stability: Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months

Reference Interval

Available Separately

Components

Reference Interval

0030113

Protein C, Functional

Effective November 17, 2014

Age	Reference Interval
1-4 days	17-53%
5-29 days	20-64%
30-89 days	21-65%
90-179 days	28-80%
180-364 days	37-81%
1-6 years	40-92%
7-9 years	70-142%
10-11 years	68-143%
12-13 years	66-162%
14-15 years	69-170%
16-17 years	70-171%
18 years and older	83-168%

0030111

Protein C, Total Antigen

1-4 days: 17-53%
5-29 days: 20-64%
30-89 days: 21-65%
90-179 days: 28-80%
180-364 days: 37-81%
1-5 years: 40-92%
6-10 years: 45-93%
11 years and older: 63-153%

0098894

Protein S Free, Antigen

Age	Male	Female
1-89 days	15-55%	15-55%
90-179 days	35-92%	35-92%
180-364 days	45-115%	45-115%
1-5 years	62-120%	62-120%
6-9 years	62-130%	62-130%
10-17 years	60-140%	60-140%
18 years and older	74-147%	55-123%

0030112

Protein S, Total Antigen

Age	Male	Female
1-4 days	12-60%	12-60%
5-29 days	22-78%	22-78%
30-89 days	33-93%	33-93%
90-179 days	54-118%	54-118%
180-364 days	55-119%	55-119%
1-5 years	54-118%	54-118%
6-10 years	41-114%	41-114%
11 years and older	84-134%	63-126%

Interpretive Data

Refer to report.

Note

If Protein C Functional is low, Protein C, Total Antigen will be added. If Protein S Free is low, Protein S Total Antigen will be added. Additional charges apply.

CPT Code(s)

85303; 85306; if reflexed add 85302; if reflexed, add 85305

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Components

Component Test Code*	Component Chart Name	LOINC
0030113	Protein C Functional	27819-2
0098894	Protein S Ag Free	27821-8

* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Protein C, Functional and Protein S Free