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Protein C, Functional with Reflex to Protein C, Total and Protein S, Free with Reflex to Protein S, Total
2003386
Ordering Recommendation

Acceptable panel to detect and subtype protein C and S deficiencies. Do not order if the individual has been on warfarin therapy in the previous 2-4 weeks.

Mnemonic
PROT C/S R
Methodology
Electromagnetic Mechanical Clot Detection/Enzyme-Linked Immunosorbent Assay/Microlatex Particle-Mediated Immunoassay
Performed
Mon-Fri
Reported
1-5 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines. 
Specimen Preparation
Transfer 4 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 2 mL) 
Storage/Transport Temperature
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered. 
Unacceptable Conditions
Serum. EDTA plasma, clotted or hemolyzed specimens. 
Remarks
 
Stability
Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months 
Reference Interval
Available Separately
Components
Reference Interval
0030113Protein C, FunctionalEffective November 17, 2014
AgeReference Interval
1-4 days17-53%
5-29 days20-64%
30-89 days21-65%
90-179 days28-80%
180-364 days37-81%
1-6 years40-92%
7-9 years70-142%
10-11 years68-143%
12-13 years66-162%
14-15 years69-170%
16-17 years70-171%
18 years and older83-168%

0030111Protein C, Total Antigen1-4 days: 17-53%
5-29 days: 20-64%
30-89 days: 21-65%
90-179 days: 28-80%
180-364 days: 37-81%
1-5 years: 40-92%
6-10 years: 45-93%
11 years and older: 63-153%
0098894Protein S Free, Antigen
AgeMaleFemale
1-89 days15-55%15-55%
90-179 days35-92%35-92%
180-364 days45-115%45-115%
1-5 years62-120%62-120%
6-9 years62-130%62-130%
10-17 years60-140%60-140%
18 years and older74-147%55-123%

0030112Protein S, Total Antigen
AgeMaleFemale
1-4 days12-60%12-60%
5-29 days22-78%22-78%
30-89 days33-93%33-93%
90-179 days54-118%54-118%
180-364 days55-119%55-119%
1-5 years54-118%54-118%
6-10 years41-114%41-114%
11 years and older84-134%63-126%


Interpretive Data
Refer to report.

Note
If Protein C Functional is low, Protein C, Total Antigen will be added. If Protein S Free is low, Protein S Total Antigen will be added. Additional charges apply.
Hotline History
N/A
CPT Code(s)
85303; 85306; if reflexed add 85302; if reflexed, add 85305
Components
Component Test Code*Component Chart NameLOINC
0030113Protein C Functional27819-2
0098894Protein S Ag Free27821-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Protein C, Functional and Protein S Free