Rheumatoid Arthritis Panel with Reflex to Rheumatoid Factors, IgA, IgG, and IgM by ELISA
Ordering Recommendation

If Rheumatoid Arthritis Panel (2003277) is positive, test reflexes to Rheumatoid Factors, IgA, IgG, and IgM, which may aid in prognostication.  Rheumatoid Arthritis Panel is preferred for initial workup of suspected rheumatoid arthritis or undifferentiated inflammatory arthritides.

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Quantitative Immunoturbidimetry/Quantitative Enzyme-Linked Immunosorbent Assay
1-4 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
Fasting specimen preferred. 
Serum separator tube (SST). 
Specimen Preparation
Allow serum to clot completely at room temperature before centrifuging. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.8 mL) Serum is the only acceptable specimen type for this test without a disclaimer. 
Storage/Transport Temperature
Unacceptable Conditions
Plasma, miscellaneous body fluid, or urine. Contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic specimens. 
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 2 weeks (avoid repeated freeze/thaw cycles) 
Reference Interval
Test Number
Reference Interval
0055256Cyclic Citrullinated Peptide (CCP) Antibody, IgG
19 Units or lessNegative
20-39 UnitsWeak positive
40-59 UnitsModerate positive
60 Units or GreaterStrong positive

0050465Rheumatoid Factor0-14 IU/mL
0051298Rheumatoid Factors, IgA, IgG, and IgM by ELISA
Test Number
Reference Interval
 Rheumatoid Factor, IgG by ELISARefer to report
 Rheumatoid Factor, IgM by ELISARefer to report
 Rheumatoid Factor, IgA by ELISARefer to report

Interpretive Data
Anti-cyclic citrullinated peptide (anti-CCP), IgG antibodies are present in about 69-83 percent of patients with rheumatoid arthritis (RA) and have specificities of 93-95 percent. These autoantibodies may be present in the preclinical phase of disease, are associated with future RA development, and may predict radiographic joint destruction. Patients with weak positive results should be monitored and testing repeated.

If CCP IgG is 20 Units or greater and/or Rheumatoid Factor is 15 IU/mL or greater, then Rheumatoid Factor, IgG/IgM/IgA by EIA will be performed. Additional charges apply.
Hotline History
View Hotline History
CPT Code(s)
86200; 86431; if reflexed, add 83516 x3
Component Test Code*Component Chart NameLOINC
0050465Rheumatoid Factor11572-5
0055256Cyclic Citrullinated Peptide Ab, IgG33935-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • CCP and RF IgA IgG IgM
  • CCP, RF, RF isotypes
  • RA
  • RA panel reflex RF
  • RF