Predicts response to anti-EGFR and MAPK pathway therapies in a variety of malignancies (eg, melanoma and colorectal cancer).
- Patient Preparation
- Collect
- Tumor tissue.
- Specimen Preparation
- Formalin fix (10 percent neutral buffered formalin) and paraffin embed tissue. Protect from excessive heat. Transport tissue block or 5 unstained 5 micron slides. (Min: 3 slides). Transport block and/or slide(s) in a tissue transport kit (ARUP supply # 47808) available online through eSupply using ARUP Connect™or contact ARUP Client Services at (800) 522-2787.
- Storage/Transport Temperature
- Room temperature. Ship in cooled container during summer months.
- Unacceptable Conditions
- Frozen specimens. Specimens fixed/processed in alternative fixatives (alcohol, Prefer®) or heavy metal fixatives (B-4 or B-5). Decalcified specimens.
- Remarks
- Include surgical pathology report. Tissue block will be returned after testing.
- Stability
- Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
2002148 | Block ID | 57723-9 |
2003124 | NRAS Mutation Detection, Pyrosequencing | 21719-0 |
- Anti-EGFR therapy resistance
- Codon 12,13
- Codon 61
- N-RAS
- RAS Mutation Analysis, Thyroid Cancer