Human Epididymis Protein 4 (HE4)
2003020
Ordering Recommendation
Not a stand-alone tumor marker for ovarian cancer screening or diagnosis.  May be used with CA-125 to monitor epithelial ovarian cancer post therapy if pretreatment levels were elevated.  Do not use in mucinous or germ-cell ovarian cancer.
Mnemonic
HE4
Methodology
Quantitative Enzyme Immunoassay
Performed
Thu, Sun
Reported
1-8 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Plain red or serum separator tube.  
Specimen Preparation
Allow specimen to clot completely at room temperature. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)  
Storage/Transport Temperature
Frozen.  
Unacceptable Conditions
Hemolyzed or lipemic specimens.  
Remarks
  
Stability
Ambient: 4 hours; Refrigerated: 72 hours; Frozen: 60 days  
Reference Interval
0-150 pmol/L  
Interpretive Data
HE4 is to be used as an aid in monitoring recurrence of progressive disease in patients with epithelial ovarian cancer. Serial testing for patient HE4 results should be used in conjunction with other clinical methods for monitoring ovarian cancer. Values obtained with different assay methods should not be used interchangeably. ARUP uses the Fujirebio Diagnostics, Inc. HE4 enzyme immunometric assay.  
Note
 
CPT Code(s)
86305
Components
Component Test Code*Component Chart Name
2003021Human Epididymis Prot 4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • HE 4
  • HE4
  • Human HE4 Antigen