Human Papillomavirus (HPV), High Risk by in situ Hybridization, Paraffin
2002899
Ordering Recommendation
Preferred in situ hybridization test to detect high-risk HPV subtypes in formalin-fixed, paraffin-embedded tissue.
Mnemonic
HPVHI ISH
Methodology
In situ Hybridization
Performed
Mon-Fri
Reported
2-5 days  
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
Specimen Required
Patient Preparation
  
Collect
Tissue.  
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin-embed tissue. Transport tissue block or 5 unstained 5-micron slides in a tissue transport kit (ARUP supply #47808). Available online through eSupply using ARUP ConnectTM or contact ARUP Client Services at (800) 522-2787. (Min: 3 slides) Protect paraffin block and/or slides from excessive heat.  
Storage/Transport Temperature
Room temperature or refrigerated. Ship in cooled container during summer months.  
Unacceptable Conditions
Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). Frozen specimens.  
Remarks
Include surgical pathology report.  
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
Negative  
Interpretive Data
This test detects genotypes: 16 and 18.

A negative result does not rule out the presence of an HPV genotype absent from the test, a low level infection, or specimen sampling error.

See Compliance Statement B: www.aruplab.com/CS  
Note
 
CPT Code(s)
88365
Components
Component Test Code*Component Chart Name
2002898HPV High Risk ISH Comment
2002999ISH Tissue Source
2003000ISH Reference Number
2003001H and E Slide Description
2003006HPV ISH High Risk
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • high-risk HPV ISH
  • HPV
  • HPV High Risk ISH
  • HPV HR ISH
  • HPVHI ISH
  • HR-HPV ISH