Human Papillomavirus (HPV), High Risk by in situ Hybridization, Paraffin
2002899
 
Ordering Recommendation
Preferred in situ hybridization test to detect high-risk HPV subtypes in formalin-fixed, paraffin-embedded tissue.
Mnemonic
HPVHI ISH
Methodology
In situ Hybridization
Performed
Mon-Fri
Reported
2-5 days
New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
 
Collect
Tissue.  
Specimen Preparation
Formalin fix (10 percent neutral buffered formalin) and paraffin-embed tissue. Transport tissue block or 5 unstained 5-micron slides in a tissue transport kit (ARUP supply #47808). Available online through eSupply using ARUP ConnectTM or contact ARUP Client Services at (800) 522-2787. (Min: 3 slides) Protect paraffin block and/or slides from excessive heat.  
Storage/Transport Temperature
Room temperature or refrigerated. Ship in cooled container during summer months.  
Unacceptable Conditions
Specimens fixed or processed in alternative fixatives (alcohol, Prefer) or heavy metal fixatives (B-4 or B-5). Frozen specimens.  
Remarks
Include surgical pathology report.  
Stability
Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable  
Reference Interval
Negative
Interpretive Data
This test detects genotypes: 16 and 18.

A negative result does not rule out the presence of an HPV genotype absent from the test, a low level infection, or specimen sampling error.

See Compliance Statement B: www.aruplab.com/CS
Note
CPT Code(s)
88365
Components
Component Test Code*Component Chart Name
2002898HPV High Risk ISH Comment
2002999ISH Tissue Source
2003000ISH Reference Number
2003001H and E Slide Description
2003006HPV ISH High Risk
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, contact interface support at interface.support@aruplab.com.
Cross References
  • high-risk HPV ISH
  • HPV
  • HPV High Risk ISH
  • HPV HR ISH
  • HPVHI ISH
  • HR-HPV ISH