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Glutamic Acid Decarboxylase Antibody (GAD65) and Insulin Antibodies with Reflex to IA-2 Antibody
2002862
Ordering Recommendation

Panel test most useful to establish autoimmune etiology in previously diagnosed type 1 DM. Do not use to differentiate type 1 DM from type 2 DM, for most cases.

Mnemonic
GADINS ABS
Methodology
Quantitative Radioimmunoassay/Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Varies
Reported
2-10 days
New York DOH Approval Status
This test is New York DOH approved.
Submit With Order
ARUP Consult®
Disease Topics
Specimen Required
Patient Preparation
 
Collect
Serum separator tube or plain red. 
Specimen Preparation
Transfer 2 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) 
Storage/Transport Temperature
Frozen. 
Unacceptable Conditions
Plasma. Hemolyzed or lipemic specimens. 
Remarks
 
Stability
After separation from cells: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 2 months 
Reference Interval
Test Number
Components
Reference Interval
0099228Insulin AntibodyEffective May 21, 2012

0.0-0.4 Kronus Units/mL
2001771Glutamic Acid Decarboxylase Antibody0.0-5.0 IU/mL
0050202IA-2 Antibody0.0-0.8 Kronus Units/mL

Interpretive Data
The Insulin Antibody assay quantitatively measures human serum autoantibodies to endogenous insulin or antibodies to exogenous insulin.

Note
If either Insulin Antibody or Glutamic Acid Decarboxylase Antibody is negative, then IA-2 Antibody will be added. Additional charges apply.

Insulin Antibody: Kronus Units are arbitrary. Kronus Units = U/mL
CPT Code(s)
86337; 83516; if reflexed, add 86341
Components
Component Test Code*Component Chart NameLOINC
0098223Insulin Antibody8074-7
2001772Glutamic Acid Decarboxylase Antibody56540-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • GAD65
  • GADAB
  • Human Insulin Antibodies
  • IA-2
  • Insulin Antibodies